2nd International Conference on Tumor Microenvironment:
Progression, Therapy and Prevention
Baden, Austria, June 25-29, 2002
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FOREWORD
The proper development and maintenance of most cellular systems requires
the influence of specialized microenvironments. Hematopoiesis, for example,
is dependent upon the microenvironment of the bone marrow. T cell
differentiation requires thymic components and the microenvironment of
mammary glands controls development and modeling of these glands. The
concept that microenvironmental factors play an important role in cancer
and in particular in metastasis formation exists for a long time. However,
the dominant notion that changes in the DNA of oncogenes and tumor
suppressor genes bear a major if not an exclusive responsibility not only
for cancer development but also for its progression overshadowed, to a
large extent, the area of tumor microenvironment.
This area was never dormant, however. An international
workshop on "In Situ Tumor Immunity "dealing exclusively with cellular and
humoral immunity in the tumor microenvironment was held in Tel Aviv in
1978. An international conference devoted to all aspects of "Tumor
microenvironment" was held on the shore of the Sea of Galilee in Israel in
1995. This was a truly multidisciplinary event where the focal issue, the
tumor microenvironment, was approached and discussed thoroughly by
specialists from a wide spectrum of biomedical sciences.
The Baden conference (June 25-29, 2002) on "Tumor
Microenvironment" met, in full, the intentions of the organizers to create
a friendly forum that promotes a critical review of novel basic findings
and of innovative clinical studies pertaining to the cancer
microenvironment. An important portion of this highly successful
scientific gathering is summarized in this volume.
It is my pleasure to acknowledge the superb work
carried out by my colleagues in the organizing committee and to thank Ron
Apte, Peter Czernilofsky, Smadar Fisher, Benjamin Sredni, Eitan Yefenof,
Israel Vlodavsky and Dov Zipori for their devotion. I also express our
gratitude to the sponsors of the conference and primarily to Boehringer
Ingelheim Austria for very generous support.
Isaac P. Witz
INDEX
The Molecular Basis of
Metastasis
Progression, Therapy and Prevention of Raf Induced Lung
Cancer in Mice
S. Storm, J. Fensterle and U.R. Rapp
PYST2, a MAPK Dual Specificity Phosphatase Is Regulated
by Microenvironmental Factors
O. Levy-Nissenbaum, O. Sagi-Assif, S.
Hantisteanu, P. Raanani, A. Avigdor, I. Ben-Bassat and I.P. Witz
Signaling and Control of Gene
Expression
Gene Regulation in the Progression and Metastasis of
Human Malignant Melanoma
E. McGary and M. Bar-Eli
Tumor – Microenvironment Interaction Modulates Gene
Expression in Multiple Myeloma
S. Yaccoby, J. Shaughnessy, F. Zhan, B.
Barlogie and J. Epstein
Overexpression of the Small Heat Shock Protein Hsp27
Affects the Metastatic Phenotype of Human Melanoma Cells In Vitro
S. Aldrian, F. Trautinger, I. Fröhlich, W.
Berger, M. Micksche and I. Kindas-Mügge
Tumor-Stroma Interactions:
Adhesion and Its Regulation
Regulation of Angiogenesis by the Extracellular Matrix
and Protein Kinase A
J. Varner
Basement Membrane Defects in Xeno-Grafts of Malignant
Human Cells
N. Mirancea, C. Schmidt, N. Daum, P. Tomakidi,
H.-J. Stark, N.E. Fusenig and D. Breitkreutz
Control of Tumor Phenotype by Stromal Modulation
M.J. Willhauck, J.C. Mertens, A. Pavesio,
N.E. Fusenig and H.J. Stark
Different Dynamics of Stromal Activation in Benign and
Malignant Epithelial Tumors
S. Vosseler and N.E. Fusenig
Adhesion and Adhesion Molecules
Carbohydrate Recognition and Metastasis
Y. Takenaka, T. Fukumori and A. Raz
Cell Adhesion, Tumor Invasion, and Metastasis
U. Cavallaro, M. Herzig, J. Niedermeyer, M.
Fuxa, B. Schaffhauser, I. Crnic, A.-K. Perl and G. Christofori
The Possible Role of Focal Adhesion Kinase (P125FAK) in
the Malignancy of Human Melanoma
O. Kahana, M. Micksche, I.P. Witz and I. Yron
Adherence Up Regulates Expression of PYST2-L in Myeloid
Leukemia Cells
S. Hantisteanu, O. Levy-Nissenbaum, O.
Sagi-Assif, P. Raanani, A. Avigdor, I. Ben-Bassat and I.P. Witz
Cytokines in the Tumor
Microenvironment
Stromal Cell-derived Factor 1 (SDF-1/CXCL12) in
Malignant Glial Brain Tumors
M. De Rossi, M. Gelati, S. Frigerio, C.
Calatozzolo, M. Eoli, B. Pollo, G. Broggi, E. Ciusani, A. Boiardi and A.
Salmaggi
Mammary Adenocarcinoma Progression: Potential Role of
Inter-relationships Between MCP-1, GM-CSF and TNF Alpha
E. Neumark, I.P. Witz and A. Ben-Baruch
IL-4 and IL 4d2 System in Host Defense Mechanism
against Allergic and Tumor Diseases
R. Vasilenko, A. Vasiliev, I. Chikileva, A.
Khodyakova, G. Puchkova, N. Kulikova, I. Kosarev, S. Andreev, L. Ptitsyn,
V. Pavlov, V. Khlebnikov, V. Uversky, M. Kiselevsky and V. Abramov
Lytic Enzymes in the Tumor
Microenvironment
Involvement of Heparanase in Cancer Metastasis,
Angiogenesis and Normal Development
E. Zcharia, O. Goldshmidt, S. Metzger and I.
Vlodavsky
Processing and Ectodomain Shedding of Membrane Type
1-Matrix Metalloproteinase and Regulation by Synthetic and Natural MMP
Inhibitors
P. Osenkowski, M. Toth, M. Bernardo and R.
Fridman
The Role of Protease Activated Receptor -1 (PAR-1) in
Tumor Invasion and Metastasis, Angiogenesis, and Mammary Gland
Morphogenesis
Z. Salah, Y.-J., Yin, M. Maoz, I. Cohen, B.
Uziely, S. Grisaru-Granovsky and R. Bar-Shavit
Dissecting the Mechanism of Matrix
Metalloproteinase-Induced Transformation of Mouse Mammary Epithelial Cells
D.C. Radisky, D.D. Levy and M.J. Bissell
Hypoxia Simultaneously Enhances Matrix
Metalloproteinase 2 and Apoptosis in Endothelial Cells
Y. Ben-Yosef, S. Shapiro, A. Miller, and N.
Lahat1
Predictive Value of Gelatinases in Urine and Analysis
of Activation Mechanism of MMP-9 for Tumor Progression
M. Zuka, T. Tanaka and Y. Okada
Tumor Immunity and
Immunotherapy
Monoclonal Antibodies in Cancer Therapy: Involvement of
FcgR Expressed by Immune Effector Cells and by Tumor Cells
L. Cassard, W.H. Fridman and C.
Sautès-Fridman
Unexpected High Frequency of Recombinant Antibodies
Endowed with the Antigen-Specific, Major Histocompatibility
Complex-Restricted Specificity of T Cells Isolated from a Large Naive
Human Library
A. Lev, G. Denkberg, C.J. Cohen, H.R.
Hoogenboom and Y. Reiter
Directing Cytotoxic T-cells to Tumor Cells by
Antibody-mediated Targeting of Single-chain Class I MHC-peptide Complexes
A. Lev, D. Segal and Y. Reiter
T Cell Memory and Immunotherapy in Breast Cancer
V. Schirrmacher
T Cell Memory to Cell-bound Antigen
Y.D. Mahnke and V. Schirrmacher
Growth Inhibition of Prostate Adenocarcinoma In Vitro
and In Vivo by Anti Her2 Immunotoxins
R. Rabinovsky, E. Zeira, E. Galun, J.W. Uhr,
E. Vitteta and E. Yefenof
Anti-cancer Mucosal Vaccines: Therapeutic Efficacy
Against Cancers Growing in Mucosal Organs
U. Qimron, N. Madar, E. Bar-Haim, L.
Eisenbach, H.F. Staats and A. Porgador
Vaccine to Combat Immunosuppressive Stroma-derived
Factor in Uterine Cervix Cancer
H. Le Buanec, B. Bizzini, A. Burny, R.C.
Gallo and D. Zagury
Identification of Novel CD44 Ligands May Provide New
Targets for Therapy
L. Melnik, M. Rochman, D. Ronen, Y. Zick, D.
Naor and I. Golan
Novel Approaches for Cancer
Therapy
The Synergistic Activity of AS101 and PMA on HL-60
Cells Differentiation: Mechanism of Action
M. Bouganim, Y. Kalechman, M. Albeck and B.
Sredni
Induction of Apoptosis by the Immunomodulator AS101 in
Ha-Ras Transformed Cells
S. Eliyahu, S. Dovrat, M. Albeck, S. Segal
and B. Sredni
Studies of Specific Activity of Human Recombinant
Lymphotoxin with the Use of Transplantable Lymphosarcoma Lio-1 Cell Line
A.A. Denisov, L.V. Mikhina, O.A. Karpova,
Y.S. Dorovatovskaya, A.V. Tretyakova, S.V. Mel’nikova, R.V. Borovick and
N.R. Dyadishchev
Prospects of Recombinant Human Prothymosin a in
Antitumor Immunotherapy
A. Khodyakova, L. Khromykh, R. Vasilenko, A.
Vasiliev, I. Brisgalov, G. Puchkova, G. Kozlovskaya, I. Kosarev, V.
Khlebnikov, V. Uversky, M. Kiselevsky and V. Abramov
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