Monduzzi Editore International Proceedings Division Home Page
July 13-16, 2002 - WASHINGTON, DC, USA
Asher Kimchi
Clinical Professor of Medicine, 
UCLA School of Medicine 
Attending Physician, Division of Cardiology, 
Cedars-Sinai Medical Center 
Los Angeles, California, USA

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This book is composed of invited lectures and free papers presented at the 8th World Congress on Heart Failure Mechanisms and Management, held in Washington, DC, USA, July 13-16, 2002.

The volume contains contributions by leading authorities on the latest research developments in Heart Failure, primarily in the areas of Molecular and Cellular Biology, Cardiomyopathies, Valvular Heart Disease, Coronary Artery Disease, Cardiac Arrhythmias and Cardiac Surgery. The information included in these articles will prove to be of great value to cardiologists and scientists involved in research and patient care.

We are indebted to the members of the scientific committees and the abstract reviewers, who provided a wealth of important suggestions during the planning phase of the Congress. To the Congress faculty and all other Congress participants, we express our thanks for the quality of their presentations and for their cooperation in submitting manuscripts in a timely fashion. Finally, we acknowledge with great appreciation Dr. Anna Rosa Sailon from Medimond Medical Publications, for her help in editing and expediting the publication of this book.

Asher Kimchi, M.D.







Molecular and Cellular Biology

Preservation of Left Ventricular Function Following Ischemia-Reperfusion by Peroxisome-Proliferator Activated Receptor-Gamma (PPAR-g) Ligands
B. Molavi, N. Rasouli, H. Chen and J.L. Mehta

Defective Sarcolemmal Phospholipid-mediated Signaling in Congestive Heart Failure
P.S. Tappia and N.S. Dhalla

Antioxidants and Heart Failure
A. Ducharme, M. White and J.-C. Tardif

Is Cell Transplantation a Viable Treatment for End-stage Heart Disease?
D. Taylor

Myoblast Cell Transplantation to Repair Myocardial Infarction Percutaneous and Surgical Delivery
N. Dib

Stem Cells As a New Approach in Cardiothoracic Surgery
B.A. Nasseri, R. Hetzer and V. Regitz-Zagrosek

Mechanisms of Myoblast Transfer in Treating Heart Failure
P. Law, Kh. Haider, G. Fang, S. Jiang, F. Chua, Y.T. Lim and E. Sim


Vascular Biology, Endothelial Function

Chronic Inhibition of Nitric Oxide Synthase Induces Hypertension and Cardiomyocyte Mitochondrial and Myocardial Collagen Remodeling in the Absence of Hypertrophy
M.A. Rossi, S.G. Ramos and C.M. Prado

Spatial Confinement of Nitric Oxide/Superoxide Signaling in the Heart
R.W. Harrison and J.M. Hare

Differential Effects of Pentaerithrityl Trinitrate and Isosorbide Dinitrate on Heme Oxygenase-1 Expression and Antioxidant Defense in Endothelial Cells
S. Oberle, A. Abate, N. Grosser, H.J. Vreman, P.A. Dennery, H.T. Schneider, D. Stalleicken and H. Schrder

Blunted Inhibition of Renal Sympathetic Nerve Discharge Induced By Central Administration of Clonidine in Rats with Heart Failure
Y.-F. Li, K. Zhang, W.G. Mayhan and K.P. Patel

Coronary Artery Endothelial Protection After Local Delivery of 17b-Estradiol
J.F. Tanguay

Space Flight-Related Endothelial Dysfunction with Potential Congestive Heart Failure
W.J. Rowe

Endothelial-Dependent Microvascular Dysfunction Related to Scintigraphic Myocardial Perfusion Defects
T.H. Schindler, P.T. Buser, U. Schirp, M. Olschewski, J. Mller, N. Magosaki, M. Pfisterer, H. Just and E.U. Nitzsche

Estrogen Effects on Vascular Cells and P42/44, P38 MAPK Activity
J.F. Tanguay, P. Geraldes and M.G. Sirois

Modulation of CRP-mediated Induction of MCP-1 by NO-donating and Coagulation Inhibiting Drugs
S. Zumhagen, E. Schulze-Bahr, R. Gradaus, P. Loh and B. Brisse


Imaging and Methodology

Substernal Epicardial Echocardiography (SEE): A New Paradigm in Postoperative Care for Heart Failure Patients
M.S. Slater, S. Agrawal, J. D. Blizzard, R.I. Lowe and A.P. Furnary

Intervention Induced Microvascular Dysfunction in Patients with Coronary Artery Diseases
J. Qian, J. Ge, G. Zhang, L. Ge, H. Chen, D. Baumgart, M. Haude and R. Erbel


Coronary Artery Disease and Heart Failure

Risk Evaluation and Accuracy of Predictive Models, in Cardiology: A Brief Review
C. Pitsavos, D.B. Panagiotakos and C. Chrysohoou

Vascular Remodeling After Myocardial Infarction: Benefits of ACE-Inhibitors and Calcium Channel Blockers
B.I. Jugdutt

Myocardial Infarction Activation of Renin-Angiotensin System Is Decreased by Enhanced External Counterpulsation
L. Lu, Z.S. Sheng, W.K. Wu, W.E. Lawson and J.C.K. Hui

Reverse Remodeling of Diastolic Function After Myocardial Infarction: Effect of Therapy
B.I. Jugdutt

Myocardial Hibernation As a Cause of Heart Failure in Acute Myocardial Infarction
J. Kiyak, G. Tshngryan and Ya. Zhukovsky

Influence of GPIIb/IIIa Receptor Blockade on Post-ischemic Myocardial Blood Flow and Tissue Necrosis in Dogs
J.G. Kingma jr.

Brain Natriuretic Peptide After Acute Coronary Syndromes Links with Cardiac and Coagulation Markers
R. Grybauskiene, J. Cimbolaityte, J. Bluzhas, P. Grybauskas, I. Vaara, R. Tamosiuniene, R. Babarskiene, D. Luksiene, B. Slapikiene and J. Janenaite


Interventional Cardiology

Intracoronary Brachytherapy in Complex Coronary Lesions
R. Beyar, E. Nikolsky, E. Grenadier, M. Bolous and L. Gruberg

Transcatheter Closure of Atrial Septal Defects in Elderly Patients with the Amplatzer ASD Occluder: Acute and Follow-up Results in 56 Consecutive Patients
K. Billinger, T. Trepels, N. Wilson and H. Sievert

Applkcations of Coronary Intervention in the Management of Ischemic Left Ventricular Dysfunction
G. Vetrovec and M. Lipinski

Improving Stent Performance: Issues Related to Re-Endothelialisation
A.H. Gershlick

Direct Stenting of Coronary Arteries: Early and Midterm Follow-up
D.G. Iosseliani and I.E. Chernishova

Changes of sICAM-1 and sVCAM-1 as Soluble Adhesion Markers After Coronary Diagnostic Angiography and Intervention
I. Rudolf, E. Schulze-Bahr, P. Loh, S. Rolf and B. Brisse

Comparison the Results of Stenting and Primary PTCA in Patients with Acute Myocardial Infarction
D.G. Iosseliani, S.V. Rogan, A.V. Arablinsky and S.P. Semitko

Usefulness of Novel Porous Balloon Catheter in Treatment of Vascular Diseases
Y. Sugiyama, T. Tomaru, M. Kanai, T. Sakurai and K. Yoshinaga

Comparative Evaluation of Early and Long-Term Follow-up of Transluminal Angioplasty and Stenting of Chronically Occluded Coronary Arteries
D.G. Iosseliani and M.V. Yanitzkaya

New Way To Detect the Important Factors Associated with Restenosis After Coronary Angioplasty
G.-P. Jong, Y.-F. Wang, K.-C. Ueng and T. Ma



Left Ventricular Structure and Dysfunction in Hypertension: A Review
P.R. Liebson

Nutritional Status, Stress, Levels of Serum Lipids and Red Blood Cells Antioxidant Enzymes in West Algerian Hypertensive Patients
D. Krouf, M. Bouchenak, B. Mohammedi, A. Cherrad, J. Prost and J. Belleville


Cardiomyopathies: Hypertrophic and Dilated

Sarcomeric and Non-Sarcomeric Causes of Familial Hypertrophic Cardiomyopathy
S.A. Mohiddin and L. Fananapazir

Inflammation and Viral Infection in Dilated Cardiomyopathy Pathogenesis and Specific Therapeutic Interventions
M. Noutsias, M. Pauschinger, U. Kuhl and H.-P. Schulthei

The Pathology of Isolated Left Ventricular Non-compaction (LVNC). A Rare Cause of Heart Failure
S.E. Hughes, P. Elliott, P. Kilner, S.Y. Ho and D. Morgan

Cardiac Performance and Morphology in End-Stage Renal Disease
M. Alpert

A Novel Signaling Pathway in GPCR-mediated Cardiac Hypertrophy
S. Takashima, M. Asakura, M. Kitakaze and M. Hori

Cardiomyopathy and Myasthenia Gravis: Connection or Coincidence?
M. Guglin, J. Campellone and K. Heintz

A Completely Reversible Severe Cardiac Dysfunction with Significant Mitral Insufficiency in Hemochromatosis A Case Report
M.D. Borzanovic, D. Kosevic, B. Borzanovic, V. Maravic, M. Peric, S. Kazic, A. Vlahovic, J.D. Vasiljevic, R. Vidakovic and B. Djukanovic

Chromium and Cardiovascular Disease
V. Juturu and J.R. Komorowski


Epidemiology, Prognostic Aspects

Congestive Heart Failure: Are There Gender Related Factors?
G. Bhat

B-Type Natriuretic Peptide Should Be Part of the Diagnostic Evaluation of Heart Failure: Implications from the Breathing Not Properly (BNP) Multinational Study
P.A. McCullough, J. McCord, R.M. Nowak, J.E. Hollander, H.C. Herrmann, P.G. Steg, P. Duc, A. Westheim, T. Omland, C. Wold Knudsen, A.B. Storrow, W.T. Abraham, S. Lamba, A.H.B. Wu, A. Perez, P. Clopton, P. Krishnaswamy, R. Kazanegra and A.S. Maisel

Prognostic Challenges in Idiopathic Dilated Cardiomyopathy: Clinical, Hemodynamic and Myocardial Biochemical Aspects
P.M. Seferovi, D. Trifunovi-Zamaklar, A.D. Risti, R. Maksimovi, D. Seferovi, D. Simeunovi and S. Stepanovi

Frequency of Diastolic Dysfunction and Normal Left Ventricular Ejection Fraction in the Community and in a Referral Population
I. Clements

Quality of Life in Heart Failure Patients. Is There a Gender Difference?
M. Hochleitner

The Prognostic Value of Circulating Soluble Cell Adhesion Molecules in Patients with Chronic Congestive Heart Failure
W.-H. Yin, J.-W. Chen, S.-J. Lin and M.S. Young


Preventive Aspects of Heart Failure

Can Referral Problems for Women Be Changed By Increasing Capacity?
M. Hochleitner

Primary Prevention in Turkish Immigrant Women
M. Hochleitner

Planning for Coronary Heart Disease Prevention in Mazandaran Province
S.M. Mousavi

Colchicine in Atypical Forms of Pericarditis in Children
A. Jurko, A. Jurko, jr., D. Pokorn, Z. Farska and A. Sparcova



Ethical Issues in Patients with Severe Heart Failure
H.J. Geschwind

Practical Implications of Drugs Which Improve Survival Versus Those That Reduce Hospitalization and Improve Symptoms and Quality of Life in Patients with Heart Failure Due to Reduced Left Ventricular Systolic Function
U. Thadani

Clinical Trials in Heart Failure
R. Hobbs

BNP in Decompensated Heart Failure: Lessons from the PRECEDENT TRIAL
A. Burger

Are ACE Inhibitors and Beta-Blockers Beneficial in Women with Heart Failure?
J. Ghali

-blocker Treatment and Risk Prediction in Heart Failure
C. Zugck and M. Haass

Outpatient Nesiritide for Decompensated LV Failure Case Studies of 17 Patients
L. Altschul, M. Masciello and G. Massaro

PST 2744, a Novel Compound to Treat HF, Improves Heart Function and Survival Rate in Cardiomyopathic Hamsters
P. Lo Giudice, A. Bellucci, G. Magni, T. Quagliata, G.G. Mattera, L. Pacifici, J.P. Gagnol and P. Carminati

Chronic Oral Treatment with PST-2744, a Novel Agent To Treat HF, Improves Heart Rate Variability in Cardiomyopathic Hamsters
P. Lo Giudice, G. Buffone, A. Careddu, G. Magni, G.G. Mattera, L. Pacifici, J.P. Gagnol and P. Carminati

Effectivity of B-receptor Blocking Agent in Children with Hyperkinetic Heart Syndrome
A. Jurko, A. Jurko jr., Z. Farska, A. Sparcova and J. Javorkova

Treatment with Verapamil Does Not Increase Exercise Tolerance in Essential Hypertensives with Latent Heart Failure
D. Matisone, A. Vitols, I. Kukulis, V. Dzerve, I. Dinne and U. Kalnins


Arrhythmias, Cardiac Pacing

The Major Issues in Selecting an Antiarrhythmic Drug in Patients with Heart Failure
J.A. Reiffel

Differential Diagnosis of Pacing System Malfunction: Focus on Biventricular Pacing
P.A. Levine

Atrial Fibrillation in Heart Failure: Cause or Modifier: Experience with AV Nodal Ablation
I.W.P. Obel and J. Daniels

Atrial Fibrillation in Young Greek Patients
D. Eleftheriadis, E. Fourla, K. Pistevou-Gompaki, V. Kouloulias, Chr. Fourlas, P. Vrizidis and N. Eleftheriadis

Assessment of Cardiac Resynchronization Therapy by Quantitative Gated Blood Pool Spect Imaging
D.C. Russell and P. Kosolcharoen

Preference For an Assortment of LV Guide Catheters To Facilitate Left Ventricular Pacing Lead Implants Amongst the Implanters
M. Bocchiardo, G. Rossetti, A. Vado, D. Hertzberger, D. Gras and C. Duby


Surgical Aspects, Valvular Heart Disease

Therapeutic Coronary Angiogenesis Using FGF-2 Protein
F. Sellke, M. Ruel, R. Laham and M. Simons

The Biology of Regurgitant Valvular Diseases: Pathophysiology of Heart Failure and Relation to Future Therapy
J.S. Borer, E.M. Herrold, S. Truter, C. Hochreiter, P. Supino, K. Krieger and O.W. Isom

Neurohormonal Changes, Inflammation, Cellular Death and Left Ventricular Function in Valvular Heart Disease
D. Anzulovi-Miroevi, G. Erente, M. Zaninotto, M. Plebani, A. Rozga and S. Dalla-Volta

New Diagnostic Methods For Heart Diseases: Cardioscopy
T. Tomaru, M. Kanai and Y. Sugiyama

Inter-Trigonal Distance and Anterior Leaflet Length Relationship in Mitral Annular Remodeling for Heart Failure
V. Vijay

Electrophysiological Evaluation of Ischemic Injury During Experiments and During Off-Pump Cardiac Surgery
R. Benetis, R. Lekas, A. Krisciukaitis, P. Jakuska and K. Lukosevicius


Surgery for LV Dysfunction, Mechanical Support, Cardiac Transplantation

Treatment of Posttransplant Hypertension: As Good As It Gets?
B. Stanek

Impact of Risk Factors on Patient Survival with Left Ventricular Assist Device Implantation as a Bridge to Orthotopic Heart Transplant
B.L. Tumilty, K. Malinowska, B.A. Pisani, J.C. Mendez, R.C. Lichtenberg, J.A. Robinson, B.K. Foy, M. Bakhos and G.M. Mullen

Ten Year Follow-up of Patients Bridged to Heart Transplant with Jarvik-7 Total Artificial Heart
G.M. Mullen, K. Malinowska, B.A. Pisani, J.C. Mendez, R.C. Lichtenberg, J.A. Robinson, R. Pifarre, B.K. Foy and M. Bakhos

Loyola University Heart Transplant Program Experience with CardioWest Total Artificial Heart
G.M. Mullen, K. Malinowska, B.A. Pisani, J.C. Mendez,
R.C. Lichtenberg, J.A. Robinson, R. Pifarre, M. Bakhos and B.K. Foy 503

Development of Database of Patients Supported by Ventricular Assist Devices
S. Hbler, E.V. Potapov, M. Loebe, B.A. Nasseri, D. Gsmann, K. Hoffmann, R. Sodian, H. Hausmann and R. Hetzer

Preliminary Results of the Italian Trial On "Demand" Dynamic Cardiomyoplasty (ITDDC)
G.L. Rigatelli, G. Rigatelli, M. Barbiero, A. Cotogni, R. Riccardi, F. Cobelli and U. Carraro

Incidence of Suspected Humoral Rejection in Heart Transplant Recipients
J.P. Naour, K. Malinowska, B.A. Pisani, J.C. Mendez, R.C. Lichtenberg, J.A. Robinson, B.K. Foy, M. Bakhos and G.M. Mullen

Failing Fontan Circulation Sheep Model and Utilization of Axial Flow Pump Preliminary Experiments
O. Reinhartz, S.H. Reichenbach, A. Ikai, R.K. Riemer and T.R. Karl



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