Multidisciplinary CongressEUROGIN 2003
Paris, France, April 13-16, 2003
This volume covers the outstanding research developments in Human
Papillomavirus Infection and Cervical Neoplasia Prevention presented
during the Eurogin 2003 International Congress on the Global Challenge of
Cervical Cancer Prevention, held in Paris on April 13-16, 2003. The
programme of the congress was devised to provide valuable information to
delegates, thanks to the participation of internationally renowned
During the conference, emphasis was put on the
importance of integrating basic and clinical research into cervical cancer
screening and prevention and on the need for international collaboration
and epidemiological studies.
The strateggering pace of new technology has enabled
investigators in both academia and industry to develop innovative
approaches to solving many of the problems that have bedevilled
gynecologists and pathologists for years. HPV DNA detection technology has
improved by orders of magnitude and may be useful for primary screening:
computers can screen Paps better than cytotechnologists; probes that can
be used in the office promise real time cervical neoplasia detection
opportunities; Pap smears using fluid-based systems have significantly
improved sensitivity; and probes for mitosis-associated proteins and other
molecular tests are being evaluated for potential use in detecting HPV
related lesions. Even the holy grail of prevention rather than treatment
of HPV caused diseases may become a reality through HPV vaccination. At
the same time, new treatment modalities are being evaluated and are likely
to lead to new management algorithms. Immune modulators and new topical
cytostatic formulations may make medical rather than ablative or
excisional procedures a reality.
While this fantastic technology is being pursued in the
developed countries, women in low resource settings continue to die from
genital tract cancers at an alarming rate. The problems relating to money,
infrastructure, competing needs, a political indifference frequently seem
insurmountable. But investigators in a dozen countries are systematically
exploring better, easier, and less expensive ways to screen underserved
women for cervical neoplasia and to treat their disease when it is
detected. These studies mesh well with advances in service delivery, and
they may all come together in the near future to provide at least partial
solutions to what was thought to be intractable problems.
We trust that the latest technological and
pharmaceutical advances presented in the scientific programme will enable
participants to identify current-day problems and provide them with the
opportunity of developing a practical policy.
The international and multidisciplinary participation
of delegates was a particularly stimulating feature. We would like to
extend grateful thanks to the contributors and exhibitors for their
generous support as well as to the organizing committee for their devoted
efforts and to Monduzzi Editions for publishing these proceedings.
Chairman of the Scientific Committee
Natural History of HPV Infections: Recent Developments
The Natural History of Vulval Intraepithelial Neoplasia
Renewing the Organised Screening Programme For Cervical
Cancer in Finland: First Results on Randomised Comparison of Primary
Screening with Traditional Pap-Smear and Automation-Assisted ScreeningP. Nieminen, A. Anttila and M. Hakama
Cervical Screening: The Challenge For the FutureJ. Patnick
HPV Transmission in FamiliesS. Syrjänen, Marjut Rintala and Seija Grenman
Geographic Variation in HPV InfectionS. Franceschi, G.M. Clifford, S. Vaccarella,
H.R. Shin, S. Sukvirach, P.T.H. Anh, E. Matos, M. Molano, J. Thomas and R.
The Story of Human Papillomavirus Infection: EMERGENCEA. Meisels
HPV Testing in Primary Cervical Cancer Screening: A
Canadian ExperienceS. Ratnam and E. Franco
Human Papillomavirus Testing in Primary Screening of
High-Grade Cervical Lesions: A Study of 12538 WomenC. Clavel, J. Cucherousset, J.P. Bory, R.
Gabriel, C. Quereux and P. Birembaut
Testing Optional Screening Tools For Cervical Cancer in
the New Independent States (NIS) Of The Former Soviet UnionK.J. Syrjänen, I.P. Shabalova, N. Petrovichev,
V.P. Kozachenko, A. Pajanidi, J.I. Podistov, G. Chemeris, L.G. Sozaeva,
Zakharova, E.V. Lipova, I. Tsidaeva, O.G. Ivanchenko, A.A. Pshepurko, S.
Zakharenko, R. Nerovjna, L.B. Kljukina, O.A. Erokhina, M.F. Branovskaja,
M. Nikitina, A. Griunberg, V. Griunberga, A. Juschenko, P. Tosi, M.
Cintorino, R. Santopietro and S. Syrjänen
Comparing Pap Smear Cytology, Aided Visual Inspection
(VIA), Screening Colposcopy, Cervico- Graphy and HPV Testing By HCII (Normal
and Self-Sampling) As Optional Screening Tools in Latin America.
Experience From the LAMS Study K. Syrjänen, P. Naud, S.M. Derchain, C.
Roteli-Martins, A. Longatto-Filho, S. Tatti, M. Branca, M. Erzen, L.
Serpa-Hammes, R. Gontijo, T.P. Lima, M.Y.S. Maeda, A. Lorincz, G.B. Dores,
S. Costa and S. Syrjänen
Cervical Cancer Screening: The Role of PAP Smear,
Hybrid Capture and Visual Inspection in the Diagnosis of Premalignant and
Cervical Cancer LesionsP. Naud, J. Matos, L. Hammes, A. Lorincz, G.
Dores, V. Magno, J. Stuczinski, P. Crussius, C. Campos, M. Barcellos, C.
Browers, M. Osanai, L. Zubaran, A. Ávila, E. Capp and J.C. Prola
Fluorescence-based Spectroscopy for Detecting
High-grade Intraepithelial Neoplasia (CIN) of the CervixA.K. Dattamajumdar, A. Ferenczy, M. Tuggy, M.
Rosing, J. Waldman, V. Hunter, J. Villella, D. Wells, J.T. Lewis and D.
Multimodal Spectroscopic Imaging of the Human Uterine
Cervix for Triage of Patients with Indeterminate Cervical CytologyT. De Santis, N. Chacktoura, D. Ferris, L.
Twiggs, L. Flowers, M. Lashgari, E. Wilkinson, S. Bambot, A. Agrawal and
Human Papillomavirus (HPV) Type Distribution in
HIV-Seropositive and -Seronegative Italian WomenM.L. Tornesello, M.L. Duraturo, L. Buonaguro,
M. Sansone, M. Di Stefano, R. Piccoli and F.M. Buonaguro
The Role of HPV in VINM. van Seters and M. van Beurden
Grading Colposcopic FeaturesS. Dexeus, D. Dexeus and M. Cararach
Diagnosis of intraepithelial Lesions of the Cervix:
Which Is the Gold Standard?X. Cortes-Bordoy, S. Crespi and J. Vinimelis
Management of CIN in PregnancyJ.-J. Baldauf, D. Hamid and A. Minetti
Is Destructive Treatment of Cervical Preinvasive
Disease Obsolete? A 13-Year Experience with Cryotherapy and LaserF.B. Guijon
European Federation for Colposcopy (EFC)J. Jordan, C. Redman, E. Dollery and E.
Correlation of Viral Integration and Viral Load Among
HPV 16-Infected WomenS.-M. Kulmala, B. Johansson, P. Peitsaro, M.
Ruutu and S.M. Syrjänen
Does Telomerase Activation Have a Role in HPV-Induced
Carcinogenesis?B. Johansson, P. Peitsaro, M. Ruutu and S.M.
Recent Progress On Fertility Preserving Treatment of
Infiltrative Cervical CancerA. Onnis
Early Invasion in Cervical CancerE. Diakomanolis
Clinician Panel: Translating Immunology Into the
PracticeI. Bourgault Villada
A Randomized, Placebo-Controlled Study of ZYC101a for
the Treatment of High Grade Intraepithelial NeoplasiaK.U. Petry, F. Garcia, M.A. Gold, L.
Muderspach, P. Braly, C.P. Crum, R.G. Urban, M.L. Hedley and K. Beach
Combi-therapy for EGW´s – Which Options? G. von Krogh
Hysteroscopic Treatment of Uterine SynechiasL. Montevecchi
Office Gynecological Procedures: Treatment of Vaginal
DiseaseE. Paraskevaidis and A. Sotiriadis
Ductal Lavage in Women at High Risk for Breast CancerV. Vogel
Current Issues in Diagnostic Testing of STIsR.W. Peeling
Other STDs IssuesJ.H.F. Smith
Rapid and Sensitive Detection of HSV in Pregnant Women
During Pregnancy and Before Labor By Direct Fluorescent Assay (DFA) with
Monoclonal AntibodiesM. Askienazy-Elbhar and M. Azoulay
Steps toward Reliable Online Health Information: the
HPV Prevalence in South of BrazilP. Naud, J. Matos, L. Hammes, J. Stuckzinski,
K. Brouwers, V. Magno, P. Crussius, A. D’Avila, C. Campos, C. Marc, M.
Hoblik and L. Oliveira
Improving Health Systems Towards Equality-based Control
of Cervical Cancer in Latin America. Comparing Pap Smear Cytology, Aided
Visual Inspection, Cervicography and Human Papillomavirus (HPV) Testing as
Optional Screening Tools in Brazil and Argentina. Multicentric Study –
Description of data from Porto Alegre - BrazilP. Naud, K. Syrjänen, L. Hammes, J.C. Matos,
M.C. Barcelos, C. Campos, E. Dias, V.A. Magno, C.E. Niederauer, C. Pereira,
R. Prati, J. Stuczinski, A. Rose, A.C. Pütten, P. Ferreira, E. Campos, M.
Branca, M. Erzen, A. Lorincz, G. Dores, O. Artigalas, F. Costa, G.
Fontana, M. Höblick, M.C. Mano, C. Marques Pereira, I. Moreira, J.G.
Olijnyk, E. Piccoli and J.G. Thome
Optical Detection of Cervical Neoplasia: Effect of
Biological and Procedural VariablesR. Cestero, R. Alvarez, W. Huh, F. Garcia, M.
Gold, R. Guido, K. McIntyre-Seltman, D. Harper, V. Soto-Wright and L.
Detection of HPV and Subtyping of HPV in Papspin Medium
Collected Cervical Cells M. Ramael and H. Van Steelandt
Detection of Cervical Neoplasia Using Non-Invasive
Fibre-Optic Confocal MicroscopyW. McLaren, J. Tan and M. Quinn
Study of Cervical Intraepithelial Neoplasia By
Calibrated Fluorescence Imaging Technique
T.H. Cheung, Tao Wu, W.K. Lo, M.Y. Yu and Jianan Qu
Optical Coherence Tomography in Diagnosis of Cervical
NeoplasiaN. Shakhova, I. Kuznetzova, T. Kachalina, N.
Gladkova, V. Gelikonov, V. Kamensky and F. Feldchtein
Evaluation of Pap Test Thin Prep (TP) Results in
Clinical PracticeH. Margari, M. Stamataki, H. Arbaniti, Sm.
Divani, M. Gavriil, N. Margari, St. Kanakakis and E. Kada
Organization and Implementation of Cervical Screening
Pilot Program in County of Cluj, TransilvaniaO. Suteu, L. Lazar, A. Irimie, F. Nicula, D.
Coza, M. Duma, R. Pais and L. Neamtiu
Management of ASCUS in Postmenopausal WomenP. Cristiani, A. Abbruzzese, M. Benedetti, G.
Cama, A. Campana, S. Costa, M. De Nuzzo, A. Galletti, P. Garutti, P.
Greci, L. Lombardozzi, P. Terzano, M. Tiboni and C. Veronesi
Coexistence of VIN and Vulvar Cancer with
Intraepithelial Or Invasive Changes within Uterine Cervix and Vagina in
Young Women As a Clinical ProblemK. Adamek and A. Basta
Detection of High Risk Oncogenic Human Papillomavirus
in Women Patient with CIN 3 LesionsG. Dinca, V. Tarlea, R. Mociulschi, M.
Ionescu and N. Coman
A Simple Procedural Modification For the Hybrid Capture
2 HPV DNA Test That Strengthens Accuracy A. Cullen, K. Modarress, S. Shults, C.
Collier and A. Lorincz
Development of a PCR Chemiluminescent Enzyme
Immunoassay (CLEIA) For Typing HPV DNAS in a Novel Microtiter FormatS. Venturoli, M. Cricca, F. Bonvicini, G.
Gallinella, E. Manaresi, M. Mirasoli, A. Roda, M. Zerbini and M. Musiani
An Audit on the Follow-up After the Treatment of
Cervical Intraepithelial NeoplasiaP. Ramanathan and V. Kaul
Modelling Colposcopy Services in the UK: Implications
of Proposed Guideline Change with Respect to a Single Mildly Dyskaryotic
Smear and Modification with HPV TestingR.J. Hadwin and P.G. Walker
The Loop Radiofrequence Electrosurgical Excision
Procedure (LEEP) in Preinvasive Squamous Cervical Lesions: Our ExperienceG. Perrini, C. Cordero di Montezemolo, S.
Mazzola, A. Ferrero and P. Sismondi
Laser Peeling For Extensive Genital HPV
Infection-Technique and ResultsM. Waligora
Quantitative Histopathology of Cervical
Intra-Epithelial NeoplasiaM. Guillaud, D Cox, K Aldler-Sthorz, A.
Malpica, G. Staerkel, J. Matisic, D. Van Niekerk, N. Poulin1 M. Follen and
Cost-Effectiveness of New Cervical Cancer Screening
Technologies: A German Health Technology Assessment and Decision AnalysisU. Siebert, G. Sroczynski, P. Hillemanns, B.
Gibis, K. Voigt, P. Aidelsburger, J. Wasem, J. Engel, D. Hölzel and S.
Comparative Evaluation of the Conventional Pap Test and
the Residual Material Left On the Pap Test Brush in Thin Prep Liquid
CytologyH. Margari, M. Stamataki, K. Kampitsis, Ch.
Stavridis, S. Boutou, M. Gavriil, N. Margari and P. Karakitsos
A Novel Function of HPV16 E6 Oncoprotein: Increase of
Cell AdhesionA. Epshtein, P. Gonen and L. Sherman
Clinical Significance of Genetic Alterations of
Chromosome 3, 7, X and EGFR Gene in Uterine Cervical Cancer ProgressionAM. Cianciulli, G. Corrado, R. Merola, E.
Vizza, R. Marzano, F. de la Iglesia Lopez, C. Vincenzoni, G.M. Galati and
Effects of Estrogens and Phyto-estrogens on EGF
Receptor ExpressionL. Salvatori, E. Petrangeli, L. Ravenna, P.
Chinzari, S. Marchionni, S. Costa, L. Frati and M.A. Russo
Carcinogenesis in Cervical PolypsM. Osuna-Pedroza
Overexpression of p16INK4a in HPV Positive and Negative
Infiltrating Cervical Adenocarcinomas J. Velasco, R. Hernández, C.L. Menéndez, C.
Macías, A. Astudillo, E. Serra, A. Alba, F. Domínguez, J. Pinto and A.
HPV Genotyping by SPF10 PCR LiPA in Combination with
Complementary Sequence AnalysisA.C. Molijn, B. Kleter, W.G.V. Quint and L.J.
An outbreak of Cervical Cancer in San Luis Potosí,
MexicoL. Rosales-Ortuño, M.T. Rodríguez-Nieto and
Human Papillomaviruses and Other Sexually Transmitted
Diseases in Croatia – Current StatusG. Grubisic and M. Grce
Evaluation of the APTIMA COMBO GEN-PROBE Technique in
the Diagnosis of Chlamydia Trachomatis Infections and Interest of
Systematic Screening For Neisseria GonorrhoeaeJ.M. Sueur, J. Orfila, F. Betsou and F.
Genital Chlamydial Infection: Epidemiology and Clinical
Manifestations in Female PatientsM. Malinova and T. Kamenov
Bone Mineral Density Can Be Predicted From Pap SmearsA. Repše-Fokter, S.K. Fokter, R. Komadina and