Proceedings of the 6th
World Congress on Trauma, Shock Inflammation and Sepsis
Pathophysiology, Immune Consequences and Therapy
Munich, Germany, March
This volume contains a substantial amount
of the free communications that have been presented during the
6th World Congress
on Trauma, Shock, Inflammation and Sepsis - Pathophysiology, Immune
Consequences and Therapy (TSIS 2004),
which was held for the first time in conjunction with the
5th International Congress on Shock
under the auspices of the
Federation of Shock Societies.
We have seen
enormous scientific progress within the past 4 years, since the last
World Congress on TSIS had been held also in Munich at the
beginning of the new millennium. In particular, new methods in the field
of molecular biology and genetics have been introduced within the
complex research of trauma, shock and inflammation. These novel
techniques should help to develop new therapeutic strategies for
critically ill patients. Therefore the major theme of this year’s
congress has been named - Trauma, Inflammation and Organ
Dysfunction in the Era of the Genome. The human and mouse genome
sequencing projects are nearly completed. The technology necessary to
harness the power of genome-wide molecular profiling is rapidly evolving
and soon will be available to all researchers who study critical illness
and injury. However, new opportunities create new challenges. In
particular, the difficulty of mining and correctly interpreting these
huge data sets is daunting. The 2004 congress provided the ideal venue
to learn about the promise of functional genomics, the limitations of
rapidly evolving technology, and the application of complex system
strategies to evaluate integrated genome-wide data sets.
major theme, the conference has been covering numerous topics within the
three major thematic sections – Cell Biology,
Pathophysiology and Clinical Management.
A most complex
conference program comprising a total of over 120 symposia and free
communication sessions with 960 individual presentations represented the
enormous actuality of the scientific information of this congress.
committee greatly appreciated the fact that numerous prestigious
scientific societies and institutions have contributed to the program
composition and have been expressing their esteem for this conference
project via most supportive cooperation and through endorsing the
conference by taking it under its auspices.
behalf of the scientific committee I would like to thank the publisher
of this proceedings volume – Medimond - Monduzzi Editore International
Proceedings Division for their interest, support and work in preparation
of this issue.
Eugen Faist, M.D., FACS
Professor of Surgery
Congress Chairman of the Scientific Committee
Effect of Profound
Hypothermia on Immune Activation in a Swine Model of Lethal Hemorrhage
Z. Chen, H. Chen, K. Honma, R. Querol, E.
A. Jaskille, N. Ariaban, K. Toruno, P. Rhee and HB. Alam
Effect of Early
Hemorrhage Control and Hypertonic Saline Solution Infusion on Tissue
Perfusion and Oxygenation Indices
M. Candido, R. Poggetti, B. Fontes and D. Birolini
OPS-imaging of the
Intestinal Microcirculation in Neonatal Piglets with LPS-induced Septic
D. Fischer, B. Richter, R.L. Schloesser, A.
Theissen and A. Veldman
The Influence of
Stimulator of Interferon Synthesis “Cycloferon” on Mucosal Immunity of
the Female Genital Tract
O. Galkina, I. Nesterov, A. Kovalenko, E.
Ailamasian and A. Totolian
Pyrrolidine Dithiocarbamate Reduced
Spinal Cord Trauma in Rats
T. Genovese, S. Cardali, A. Conti, R. Di Paola, and S. Cuzzocrea
Resuscitative Fluid-induced Human
Neutrophil Activation Correlates with Changes in Expression of Redox-sensitive
V. Gushchin, H.B. Alam, J.R. Kirkpatrick, P.
Rhee and E. Koustova
Acid from Staphylococcus Aureus Exhibits CD14-dependent but
R.M. Haston, M. Triantafilou and K.
Effects of Diaspirin Crosslinked
Hemoglobin (DCLHb) on the Microcirculation of Striated Skin Muscle After
Resuscitation From Severe Hemorrhagic Shock
S. Hungerer, D. Nolte, V. Bühren and K. Messmer
Activation of Protease Activated
Receptor-1 Influences Inflammatory Cytokine Production in Monocytes
S. Imahara, S. Jelacic, R. Maier and G.
Effect of Resuscitation Strategy on
Extracellular Matrix: Choice Between Destruction and Protection
R. Inocencio, H. Chen, H.B. Alam, P. Rhee and
Abnormal Dependence of O2 Consumption
on O2 Delivery and Disproportion in Splanchnic Circulation During
Endotoxin Shock in Rabbit
Hepatic Injury After Hemorrhage and
Resuscitation in Rats: Influence of Novel Resuscitation Fluids
A. Jaskille, H.B. Alam, P. Rhee, J.
Kirkpatrick and E. Koustova
Surgical Trauma-induced Inflammatory
Response and Relative Adrenal Insufficiency
M. Kashiwabara, M. Miyashita, T. Nomura, H.
Makino, H. Maruyama, T. Matsutani, M. Katsuta, K. Takahashi, K. Sasajima,
K. Yamashita and T. Tajiri
Modulation of the IL-6 Response to
Traumatic Brain Injury (TBI) by a Tibia Fracture in Rats
M. Maegele, P. Riess, B. Bouillon, M. Brockmann,
S. Hess, S. Sauerland, T.K. McIntosh, A. Mautes and E.A.M. Neugebauer
NF-kB in Hyperoxic Cell Injury and Cell
L. Mantell, D. Morrow and W. Franek
Reversibility of Aging/Precancerous
Changes of Gastric Mucosa: An Interventional Trial
F. Marotta, R. Barretto, H. Tajiri, J. Bertuccelli, P. Safran, H.
Fuji and E. Fesce
A Novel Dietary Supplement Improves
Inflammatory Changes in an Experimental Influenza-Model: A Clue to
J. Cervi, C. Bater, K. Masulair, F. Marotta,
R.A. Valentine, E. Minelli, M. Harada, P. Safran and S.H. Sha
Expression of Toll-like Receptors
Regulates the Immune Function in Mice Polymicrobial Peritonitis Model
A. Matsuda, K. Furukawa, H. Suzuki, H.
Maruyama, Y. Akiya, T. Matsutani and T. Tajiri
CYFRA 21-1 Levels in Bronchoalveolar
Fluid Indicate the Broncho-Epithelial Damage
T. Matsutani, M. Miyashita, K. Sasajima, H.
Maruyama, T. Nomura, H. Makino, Y. Tsuchiya, N. Hagiwara, R. Futami, M.
Kashiwabara, M. Katsuta, A. Matsuda, K. Takahashi, S. Suzuki, K. Egami
and T. Tajiri
The Subcutaneous Mouse Model
Represents an Artificial Test System for Drug Screening
A. Parra, I. Funke, K.-W. Jauch and B. Mayer
Relationship Between Plasma Levels of
ET-1, MMP-9, sFas, TNFa and IL-8 and Clinical Characteristics of Septic
D. Mikic, M. Cucuz, S. Vasilijic, M. Djokic
and M. Colic
Increased Levels of Serum Sulfite in
Patients with Acute Pneumonia
Comparison of Cytokine Response in
Different Mouse Strains and Sepsis Models
E.M. Muchitsch, K. Zimmermann, S. Kubik, H.
Schwarz and F. Scheiflinger
CCR1-Deficient Mice Show Enhanced
Innate Immune Responses and Are Protected in a CLP Model of Sepsis
T. Ness, K. Carpenter, J. Ewing, C. Hogaboam
and S. Kunkel
Effects of Ulinastatin, a Human
Trypsin Inhibitor, on Macrophage Mediator Production Induced by
H. Ogawa, S. Ogura, J and A. Cook
Immunoglobulins Alter Phenotype and
Function of Macrophages (MF) and May Induce Cell Death
Th.W. Orlikowsky, B. Spring, G.E. Dannecker,
J. Bauhammer, M.K. Hoffmann and C.F. Poets
Phenotypic and Functional
Characteristics of Rat Inflammatory Dendritic Cells
J. Popovic, D. Savic, D. Vucevic, V. Pavlovic,
S. Vasilijic, S. Gasic, I. Majstorovic and M. Colic
AM3 (Inmunoferon®) Decreases CD62L
Expression in Human Peripheral Blood Phagocytic Cells
E. Reyes, J.L. Alonso-Lebrero, A. Brieva, A.B.
Mallo, J.P. Pivel and M. Alvarez-Mon
Alternative (Non-animal) Method For TNFa
E. Reyes, J.L. Alonso-Lebrero, A. Brieva, A.B. Mallo, M.D. Valdes-Hevia,
J.P. Pivel and M. Alvarez-Mon
Peritoneal Macrophages Inflammatory
Acute Response After Carbon Dioxide Insufflation
CpG ODN Stimulation of Whole Blood
Alters Granulocyte Activation and Life Span
R. Smith, T. Chong, M. Hughes, T. Hedrick, K.
Du, T. Pruett and R. Sawyer
Epinephrine-Mediated Suppression of
Inflammatory Signaling Is Mediated Via PKA-Independent Pathways
K. Staudenmayer, G. O’Keefe and R. Maier
Lactated Ringer’s Does Not Increase
Inflammation after Shock
S.I. Brundage, N.A. Zautke, J. Watters, J.A.
Stefater, S.R. Todd, J.C. Lam and M.A. Schreiber
Effects of NOS Inhibitors on the
Endotoxin Shock of Dogs — In Comparison with Catecholamines —
H. Suga, T. Nakagawa, Y. Soga, Y. Deguchi, T. Terada, T. Ono, T.
Suzuki, Y. Imamura and M. Fukuda
Evaluation of Cytokine-related Gene
Expression Changes in Lymphocytes After Burn Insult
T. Tarui, A. Murata, R. Yoshie, T. Matsuda, Y.
Tomita, T. Wada, A. Wakizaka and S. Shimazaki
Defective Production and effect of
IL-18, IL-12, and IFN-g in Cord Blood Cells Influences CD80 and CD86
Expression on Macrophages
L. Tewes, B. Spring, J. Löffler, G.E.
Dannecker, Ch.F. Poets,
M.K. Hoffmann and Th.W. Orlikowsky
Changes in Circulating and
Cerebrospinal Fluid Cytokines of Patients with Various Central Nervous
Diseases and Trauma
Y. Tomita, A. Murata, T. Tarui, T. Matsuda, A. Yamamoto, N.
Matsuura and S. Shimazaki
Ozone (O3) Prior To Sepsis Is
A. Torossian, S. Ruehlmann, M. Middeke, W.
Lorenz, H. Wulf and A. Bauhofer
Differential Modulation of Toll-Like
Receptor Expression and PI3K/Akt Activity in Endothelial Cells by LPS
D. Williams, T. Ha, J. Cook, W. Browder, T.
Ozment-Skelton and C. Li
The Correlation Between MCP1 and the
Arthritis of SLE Among Chinese
D.Q. Ye, Y.S. Hu, X.P. Li, S.G. Yang, J.H. Hao,
F. Huang, G.Q. Zhang and X.J. Zhang
Parthenolide, an Inhibitor of NF-kB,
Reduces the Inflammatory Response in Hemorrhagic Shock in the Rat
B. Zingarelli, P.W. Hake, T. Burroughs and M.
Impaired Mitochondrial Function and
Structure in the Liver During Subacute Sepsis
E. Crouser, C. Cook, M. Julian and J. Huff
Different Shapes of LPS Induce the
Formation of Different Receptor Clusters
M. Triantafilou, K. Brandenburg, S. Kusumoto, K. Fukase, A. Mackie, U.
Seydel and K. Triantafilou
Long-term Immunosuppression in Septic
C. Benjamim, S. Lundy, C. Hogaboam, N. Lukacs
and S. Kunkel
Attenuation of TNF-a Production by
Immunotolerance but not Thermotolerance is Associated with Survival
Benefit in Septic Mice
I. Brennan, J.H. Wang, W.O. Kirwan and H.P.
Calpain Inhibitor I Reduces Intestinal
Ischemia-Reperfusion Injury in the Rat
R. Di Paola, S. Marzocco, G. Autore, E. Mazzon, A. Pinto, A.P. Caputi,
C. Thiemmermann and S. Cuzzocrea
Rosiglitazone, a Ligand of the
Peroxisome Proliferator-Activated Receptor-Gamma (PPAR-g) Reduces the
Development of Non Septic Shock Induced by Zymosan in Mice
S. Cuzzocrea, B. Pisano, L. Dugo, A. Ianaro, N.S.A. Patel, R. Di
Paola, T. Genovese, P.K. Chatterjee, F. Fulia, E. Cuzzocrea, M. Di Rosa,
A.P. Caputi and C. Thiemermann
Is Research in Splenectomised Dogs
G. Kemming, J. Messick, G. Enders, W. Mueller
and E. Thein
Abdominal Irradiation: A model of
Severe Trauma and Inflammation
P. Monti, A. Van der Meeren, J. Wysocki and N.M.
Adenoviral Gene Transfer of an NF-kB
Super-Repressor Increases Collagen Deposition in Rodent Cutaneous Wound
J. Schreiber, P. Efron, L. Moldawer and A. Barbul
Genetic Risk Factors for the
Prognosis of Severely Injured Patients
T. Menges, S.G. Little, A. Bohnert, J. Stricker,
K. Weismüller, T. Chakraborty, G. Hempelmann and G. Bein
Multiple Organ Failure in Severely
B. Husain, S. Ruchholtz, C. Waydhas and D.
Hemodynamically Unstable Pelvis
Fractures Continue To Be Life Threatening
W. Smith, M. Shannon, R. Grosskreuz, S.
Morgan, E. Moore, J. Moore and R. Franciose
Tissue Management with Fleece-Bound
R.T. Carbon, A. Schmidt, S. Baar and S.
Critical Illness Myopathy (CIM):
Evidence for a Myotoxic Low-molecular Weight Factor in the Serum of
Patients After Severe SIRS
O. Friedrich, E. Hund, W. Hacke and R.H.A. Fink