New Trends in Alzheimer and Parkinson Disorders:
ADPD 2005

Collection of Selected Free Papers of
the 7th International Conference on Progress in Alzheimer’s and
Parkinson’s Disease (AD/PD)

Sorrento, Italy, March 9-13, 2005




This is the second book in a series of companion pieces to the bi-annual conferences on Alzheimer’s and Parkinson’s diseases (AD/PD). The first one was published, also by Medimond, in 2003. This book contains 42 papers written by selected authors, who had presented their research at the 7th International Conference on Alzheimer’s and Parkinson’s Diseases: Clinical and Preclinical Perspectives (AD/PD 2005), that took place on March 9-13, 2005 in enchanting Sorrento, Italy. The official proceedings (OP) of the Conference will be published early in 2006 by Springer.
The Sorrento meeting included over 1,300 scientific participants, and was the venue for several hundred invited talks, general talks, posters, and symposia. It was impossible to include all of the important scientific information presented at the meeting under one cover while, at the same time, meeting publishers’ cost and profit considerations. We, the co-organizers, therefore decided to restrict contributions to the OP to chapters based on oral, invited presentations at the meeting.
Medimond has partnered with us to provide an outlet to the many topics of excellent research presented in Sorrento that, for the above reasons, are not represented in the OP. This book therefore expands the scope of available information from the official AD/PD 2005 proceedings that will follow.
Medimond’s policy is to provide rapid publication of conference proceedings. Thus, in the interest of saving time and allowing rapid publication, we agreed with the publishers’ request that we would only correct major mistakes or errors in scientific logic and fact. We would not concern ourselves with stylistic differences in expression by authors whose first language is other than English, nor with differences in font type, style, or referencing in these chapters. We have also not been too particular in the choice of chapters that have been included in the book, in order to encourage diversity in the topics presented. Each author is solely responsible for the information provided in his/her chapter, and the subject matter included does not necessarily represent the concurrence of the editors.
A more thorough and rigid editorial process will be employed in the case of the OP document.
We trust that this book (and the accompanying CD) will provide the reader with a broader overview of the breadth and richness of the program of the AD/PD 2005 conference. In particular, we would like to thank the authors of the chapters in this book, for their understanding of the topic-selection dilemma, and for going along with Medimond’s conditions for publication. The important work of these authors, presented at AD/PD 2005, thus gets to be expressed as well, and even sooner than the official document from the conference.

A. Fisher, Ph.D. I. Hanin, Ph.D. F. Stocchi, M.D. M. Memo, Ph.D.







The Influence of Genotype on Lipid Parameters in Alzheimer Disease
L. Fernández-Novoa, V.R.M. Lombardi, S. Seoane, I. Etcheverría, L. Corzo and R. Cacabelos

Functional and Structural Domains of the 5’–Flanking Regions of the BACE1 Gene Promoter: Implications in Alzheimer’s Disease
D.K. Lahiri, Y–W. Ge, B. Maloney, G. Thiel, N.H. Zawia, N.H. Greig and K. Sambamurti

Phosphorylation and Aggregation of Protein Tau in Humanized Yeast Cells and in Transgenic Mouse Brain
T. Vandebroek, D. Terwel, T. Van Helmont, J. Winderickx and F. Van Leuven

Assembly of Filamentous Aggregates Elicited in Tau Transfectant M1C by Chloroquine Treatment
T. Hamano, L. Ko, W-L. Lin, M. DeTure and S-H.C. Yen

Components Enhancing a-synuclein Aggregation and Toxicity in a Humanized Yeast
K. Pellens, P. Zabrocki, T. Vanhelmont, T. Vandebroek, G. Griffioen, S. Wera, F. Van Leuven and J. Winderickx

A Novel Regulator of Calcium/Calmodulin-Dependent Signaling
S.V. Rakhilin, P.A. Olson, A. Nishi, N.N. Starkova, A.A. Fienberg, D.J. Surmeier and A.C. Nairn

Amyloid-b-Peptide Activates the Neuronal c-Abl Tyrosine Kinase/ p73 Signaling Pathway
A. Alvarez, N. Leal, G. Cancino, P. Castro and K.S. Kosik

A Gamma-Secretase Independent Function of PS1 Links Cell-Cell Adhesion to AD Pathology; Effects of PS1 FAD Mutations
L. Baki and N.K. Robakis

Multiple in vitro Assays Provide no Evidence for an Interaction Between hAb1-42 and the ha4b2 nAChR
K. Finlayson, J. Hodgkiss, N. Crawford, J. McLuckie and J. Sharkey

Lysosomal Enhancement with Microbial Hydrolases: A Novel Strategy for Removing Protein Aggregates
A. de Grey

Lysosomal Modulation and Autophagic Induction: Compensatory Processes in Response to Protein Deposition Pathology
L. Batey, D.J. Chin, S. Karim, D.A. Karanian, D. Butler and B.A. Bahr

Peroxisomal Proliferation Prevents b-Amyloid Neurodegeneration
M.J. Santos, R.A. Quintanilla, J.A. Godoy, A. Toro and N.C. Inestrosa

Activation of NF-kB c-Rel Complexes Reduces Neuron Susceptibility to Amyloid b Peptide
I. Sarnico, F. Boroni, M. Benarese, H-C. Liou, P.F. Spano and M. Pizzi

Development of Inhibitors of Pathological Tau hyperphosphorylation for a Disease Modifying Approach to Alzheimer’s Disease
H. Sahagún, G. Hübinger, H. Klafki, S. Gordon, S. Ferrand, S. Mühlbacher, S. Müller, P. Seneci, B. Monse, W. Fröhner, L. Casiraghi, O. Thillaye du Boullay, T. Braxmeier, S. LeCorre, L. Dirscherl, C. Jolivalt, G. Lahu, I. Sobek-Klocke, N. Plesnila, M. Hutton and H. Roder

TNF-a Synthesis Inhibitors on the 3-Phthalimidoglutarimide Backbone as Therapeutic Candidates for Neurodegenerative Diseases
D. Tweedie, T. Giordano, Q.-S. Yu, W. Luo, H.W. Holloway, R.S. Pyle, A. Brossi, K. Sambamurti, D.K. Lahiri and N.H. Greig

b-amyloid Neurotoxicity Involves TNF-related Apoptosis Inducing Ligand (TRAIL) Pathway: The Role of Free Radicals
D. Uberti, T. Carsana and M. Memo

Possible Role of the Olfactory System in Alzheimer’s Disease Genesis
N.V. Bobkova, I.V. Nesterova, N.I. Medvinskaya, I.Y. Aleksandrova, A.N. Samokhin, J.G. Gershovich, P.M. Gershovich and V.A. Yashin

Effect of Chronic Lithium Treatment in an Animal Model of Tauopathies
H. Nakashima, T. Ishihara, J.Q. Trojanowski and V.M.-Y. Lee

b-Amyloid and Tau Pathology in the Aged Cynomolgus Monkey Brain (Macaca fascicularis)
K. Niggemann, R. Brandt, S. Friderichs-Gromoll, G. Habermann, J. Kaspareit and E. Buse

Modulation of Intracellular Amyloid –b-Peptide Aggregation by Copper in Caenorhabditis elegans
A. Minniti, P. Grez, C. Opazo, I. Volitakis, R. Cherny, C. Masters, A. Bush and N. Inestrosa

Searching for an Animal Model for Parkinson’s Disease Using
A. Recchia, D. Rota, D. Guidolin, P. Debetto, A. Negro and P. Giusti

Catecholamine-related Enzyme Affecting Behavior
N. Asada

Effects of H1 and H2 Histamine Receptors and Muscarinic Cholinoceptors on Memory Retention in Rats
M. Eidi and A. Eidi

Effects of Permethrin on Muscarinic Cholinergic Receptors in Mouse Striatum
Sathaporn Prutipanlai, Sukumal Chongthammakun, Pawinee Piyachaturawat, Orapin Wongsawatkul, Piyajit Watcharasit and Jutamaad Satayavivad

Effects of Vitamin E and Acetylcholine on Memory Retention of Passive Avoidance Learning in Rats
A. Eidi, M. Eidi and G. Mahmoodi

Grades of Cognitive Impairments Studied by Dual Assessments of Elderly Persons
K. Sakamoto, C. Nakayashiki, M. Hida, F. Sakamoto and N. Ishiko

Factors Influencing Caregiver Burden in AD Patients: The Key Role of Dependency
S. Andrieu, N. Despiegel, C. Guilhaume and B. Vellas

Cachexia of Idiopathic Parkinsonism Disease Viewed as an Immune/Inflammatory Process
S. Dobbs, J. Dobbs, C. Weller, N. Oxlade, A. Charlett, A. Price, I. Bjarnason and R. Kerwin

Controlling Hallucinations/Delusion in Patients with Parkinson’s Disease
K. Hasegawa, E. Horiuchi and H. Kowa

Direct Comparison of Spatially Normalized FDG-PET and ECD-SPECT Scans in Alzheimer’s Disease and Mild Cognitive Impairment
A. Okumura, S. Fukuyama, J. Shinoda and T. Iwama

Alterations in the Planum Temporale in Patients with Alzheimer Disease Estimated Via a New Volumetric Method
P. Zach, Z. Kristofiková, E. Majer, P. Selinger and D. Øípová

Rehabilitation of Anosognosia in Patients with Alzheimer’s Disease: A Pilot Study
M.J. Al Aloucy, Ch. Pélissier, A. Boudebza,
M. Roudier and G. Dalla Barba

Standardized Multiparameter Quantification of Biomarkers for Alzheimer’s Disease in Cerebrospinal Fluid
H. Vanderstichele, L. Demeyer, K. De Roo, S. Van Remoortere, V. Mortier, A. Olsson, L. Vandecasteele, V. Kostanjevecki, K. Blennow and E. Vanmechelen

Glutathione S-Transferase P1 (GSTP1) AND Apolipoprotein E (APOE) Gene Polymorphisms in Parkinson’s Disease
F. Mastaglia, E. Bolitho, F. Van Bockxmeer and M. Garlepp

Dopamine Receptor D2 (DRD2) and COMT Polymorphisms in Parkinson’s Disease
Y. Lee, E. Bolitho, F. Mastaglia and M. Garlepp

Shift in the BAlance of TRKA and pro-NGF in Prodromal Alzheimer’s Disease
E.J. Mufson, S.E. Counts, S. Peng and M. Fahnestock

Alteration of Immune Function and Lymphocyte Apoptosis in Patients with Alzheimer’s Disease (AD)
V.R.M. Lombardi, I. Etcheverría, L. Fernández-Novoa, S. Seoane and R. Cacabelos

Frontal Variant in PS1 Mutated Families: Does a Pure Clinical Picture of Alzheimer’s Disease Exist?
G. Puccio, R. Colao, S.A.M. Curcio, F. Frangipane, M. Mirabelli, L. Bernardi, C. Tomaino, R.G. Maletta, J.F. Foncin and A.C. Bruni

Is Decreased pro-BDNF the Cause of Alzheimer’s-Associated Neurodegeneration and Cognitive Decline?
M. Fahnestock, S. Peng, D. Garzon and E.J. Mufson

Neurobiological Basis of BPSD in Alzheimer’s Disease
K. Meguro, T. Tomoko, M. Tashiro, Y. Tanaka, H. Ishii and M. Itoh

Ispronicline: Safety, Tolerability, Pharmacokinetics and Pharmaco EEG Changes in Volunteer Studies
G.C. Dunbar

A “Yang-invigorating” Chinese Herbal Suppository Preparation Relieves Symptoms in Patients with Parkinson’s Disease
K.M. Ko, K. Chan, L. Shek, J. Yeung and S.H. Chui

True Healing of Alzheimer’s Disease by Holistic Homoeopathy
D. Patel

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