Progress in Coronary Artery Disease

Proceedings of the 6th International Congress on Coronary Artery Disease

(October 29 – November 1, 2005, Istanbul, Turkey)





Basil S. Lewis
Director, Department of Cardiovascular Medicine
Lady Davis Carmel Medical Center
Louis Edelstein Professor of Medicine and
Medical Research
Ruth and Bruce Rappaport School of Medicine
Technion-Israel Institute of Technology
Haifa, Israel

Zeki Ongen
Professor of Medicine
Department of Cardiology
Cerrahpasha Medical Faculty
Istanbul University
Istanbul, Turkey

Moshe Y. Flugelman
Director, In-Patient Cardiology
Lady Davis Carmel Medical Center
Senior Lecturer
Ruth and Bruce Rappaport School of Medicine
Technion-Israel Institute of Technology
Haifa, Israel

David A. Halon
Director, Interventional Cardiology
Lady Davis Carmel Medical Center
Clinical Associate Professor
Ruth and Bruce Rappaport School of Medicine
Technion-Israel Institute of Technology
Haifa, Israel



In the last few years we have witnessed a paradigm shift in our concept and management of coronary disease. Space-age technologies provide exquisite cardiac imaging, we use immediate revascularization in patients with acute coronary events, and at a molecular and cellular level we are investigating a new world of gene and cell therapy designed to promote vascular and myocardial repair. Epidemiology and prevention have been transformed by new understandings and new drugs which promise to impact dramatically on the incidence of disease.
This book presents chapters based on material presented at ICCAD6 - the 6th International Congress on Coronary Artery Disease, held in Istanbul, Turkey, on October 29 – November 1, 2005. We thank most sincerely the Congress faculty and participants who spent long hours preparing chapters for this publication and the Medimond International Proceedings Division for their excellent and efficient publication procedures. Our thanks are also due to the pharmaceutical and manufacturing industry, whose generous support made the Congress possible, to Kenes International Congress Organizers, and to our colleagues, friends and families for their never-ending help, support and advice in the arranging and planning of this meeting.

Istanbul, October 2005
Basil S. Lewis
Zeki Ongen
Moshe Y. Flugelman
David A. Halon





Angiogenesis, Gene Therapy

The Correlation of Serum VEGF Levels with Left Ventricular Remodeling in Patients with Acute Myocardial Infarction
D. Antonatos, S. Patsilinakos, S. Spanodimos, S. Likousi, V. Touliatou, P. Korkonikitas, K. Sotirelos and D. Tsingas

Cell-Free DNA Levels Are Associated with the Size of Necrosis in AMI (Preliminary Results)
A. Destouni, D. Antonatos, C. Vrettou, J. Traeger-Synodinos, S. Patsilinakos, S. Spanodimos, D. Tsigas and E. Kanavakis

Association of Vascular Endothelial Growth Factor Gene Polymorphisms with the Clinical Outcome in Patients After Myocardial Infarction
P. Douvaras, D. Antonatos, K. Kekou, S. Patsilinakos, D. Tsigas and E. Kanavakis

Comparison of the Bone Marrow Stem Cells CD34+ Releasing in the Peripheral Blood of Patients with Acute Myocardial Infarction and in Patients with Stable Angina Pectoris Subjected to Coronarography and Coronary Angioplasty
J. Kudlicki, A. Dmoszynska, T. Widomska-Czekajska, A. Brzozowski, W. Legiec, A. Goracy, M. Legiec, J. Baszak and P. Klimek



Basic Research

Nanoparticle Delivery of Anti-Restenotic Drugs
N. Kipshidze, P.L. Iverson, T.R. Porter and S.J. Adelman

Estrogen, Heat Shock Proteins and the Cardiovascular System
A.A. Knowlton, F.N. Mbai and K.L. Hamilton

Role of LMNA in Causing Heart Disease
A. Lüdtke, J. Buettner, S. Spuler, A. Grüters-Kieslich, S. Wiegand, K.J. Osterziel, A. Perrot, K. Pethig and H.H.-J. Schmidt

The Role of Cytokines and CRP in the Secretion of Vascular Endothelial Growth Factor After Acute Myocardial Infarction
D. Antonatos, S. Patsilinakos, S. Likousi, S. Spanodimos, V. Touliatou, N. Nikolaou, G. Filippatos, P. Paraskevopoulou and D. Tsingas

Expression of Myogenin and Myogenic Factor 5 in Human Adult Mesenchymal Stem Cells After 5-Azacytidine Stimulation
C. Bunu, E. Deak, I. Siska, G. Tanasie, V. Ciocotisan, D. Danila and V. Paunescu

Pleiotropic Effects of ACE Inhibitors and Statins and the Collagen Matrix
B. Jugdutt




Traditional and Emergent Cardiovascular Risk Factors Among Patients with Acute Coronary Syndrome in Presence or Absence of Peripheral Arterial Disease
A. Huelmos, J. Jimenez, C. Guijarro, J.C. Belinchon, F. Cava, E. Puras and L. López-Bescos

Intima Media Thickness in Relation with Ambulatory Blood Pressure Monitoring Characteristics and Metabolic Disorders in Hypertensive Patients with Metabolic Syndrome – Study on 105 Patients
M. Radoi, G. Ifteni, H. Rus and Gh. Pamfil



Pathophysiology of Coronary Disease

Current Views on Coronary Artery Ectasia
Ç. Erol

Natural History of Perinatal Coronary Atherosclerosis
L. Matturri, G. Ottaviani and AM. Lavezzi

Inflammatory Markers of Cardiovascular Organ Damage in Patients with Coronary Artery Disease
I. Riečanský and D. Skultétyová

Hypertension, Laminar Flow and Normal Shear Stress or Normotension, Turbulent Flow and Low Shear Stress Cause Distinct Aorta Remodeling
C.M. Prado, S.G. Ramos, J.C.F. Alves-Filho, J. Elias Jr, F.Q. Cunha and M.A. Rossi

Menopause Changes the Long-term Heart Rate Variability
T. Banach, L. Dobrek, A. Furgala, W. Kolasinska-Kloch and P.J. Thor

Persistence of anti Chlamydia Pneumoniae Antibodies at 30 Days and Evolution with Major Cardiovascular Events at 3 Years in Patients with Acute Coronary Syndromes
M. Radoi, I. Agache, E. Bobescu,
M. Anghel and L. Duca



Epidemiology and Risk Factors

The Metabolic Syndrome: Risk Factor for the Development of Acute Coronary Syndromes
I. Burazor, M. Burazor, S. Stefanovic, A. Stankovic, G. Cvetanovic, Z. Bogdanovic and N. Burazor

Acute Cardiovascular Complications Due to Physical Exercise in the Elderly
Z. Duraković, M. Misigoj-Duraković and J. Skavić

Does Selenium Blood Concentration Reflect Risk of Coronary Artery Disease in Diabetic Patients?
V. Soska, J. Olsovsky and I. Kunert



Endothelial Function

The Effects of Nebivolol on Intimal Hyperplasia
I. Akar, A. Rahman, O. Burma, B. Ustundag, A. Uysal, I. Hanefi Ozercan and E. Ilkay

Impact of Preoperative Intravenous Nitroglycerin on In-Hospital Outcomes After Coronary Artery Bypass Grafting for Unstable Angina
I. Ali, K. Buth and A. Maitland

Selected Markers of Endothelial Dysfunction in Patients with Stable Angina Pectoris and Past Chlamydia Pneumoniae Infection
D. Drobniak-Hełdak, W. Kolasińska-Kloch, R. Rajtar, A. Furgała, M. Kloch, B. Kieć-Wilk and A. Dembińska-Kieć

Inflammatory Markers, Heat Shock Protein 60 and Chlamydia pneumoniae Infection in Patients with Stable Coronary Artery Disease
R. Rajtar, W. Kolasińska-Kloch, M. Kloch, B. Kieć-Wilk, Ł. Partyka, A. Zdziennicka and A. Dembińska-Kieć

Combined Assessment of Endothelial Function and Echocardiography Markers of Myocardial Ischemia
S. Ilic, M. Deljanin Ilic, G. Kocic, R. Pavlovic and I. Stojanovic

Acute Coronary Syndromes and Acute Myocardial Infarction
Remodeling After Reperfused Myocardial Infarction: What More Can We Do?
B. Jugdutt

Acute Myocardial Infarction on the Ground of Henoch-Schoenlein Purpura in a Young Patient
D. Eleftheriadis, P. Vrizidis and N. Eleftheriadis

Relation between Myocardial Blush Grade and Ventricular Late Potential in Patient with AMI Undergoing Primary PCI
S. Okino, S. Fukuzawa, S. Ozawa, J. Sugioka, M. Inagaki, Y. Tsuru and S. Ichikawa

Epidemiological and Clinical Differences Between Women and Men Treated with Primary Angioplasty in ST-Elevation Myocardial Infarction: The Truth or a Myth?
M. Negrusz-Kawecka, M. Protasiewicz, W. Kuliczkowski, A. Derkacz, R. Poreba, E. Niedzielska and W. Mazurek

Endothelial Function in Patients with ST-elevation Myocardial Infarction Treated with Primary Angioplasty
M. Negrusz-Kawecka, R. Poręba, A. Derkacz, M. Protasiewicz and W. Mazurek

Estimation of Necrotic Size Area After Myocardial Infarction and the Influence of Fibrinolytic Therapy on Myocardial Enzymes Trends in Patients with Acute Myocardial Infarction
D. Tint, M. Radoi and Gh. Pamfil



New Diagnostic Methods
The Use of Exercise Impedance Cardiography as a Screening Test for Detecting Ischemic Heart Disease
E. Klainman, G. Bott-Kaner, M. Stanetzky, I. Shniper and G. Fink

Respiration Influences on Transmitral Doppler Flow and Arterial Stiffness
W.T. Li, C.H. Hsu, W.C. Tsai, Y.W. Liu, L.M. Tsai, C.H. Lee,
J.Y. Chen, L.J. Lin and J.H. Chen

Left Ventricular Opacification in Dobutamine Stress Echocardiography
M. Sherif-Hashem

Digital Processing of Laser-induced Fluorescence Images – A Novel Approach to Diagnosing Atherosclerosis
M. Wawrzyńska, D. Biały, Z. Kulas, E. Pawlik, P. Ziółkowski, J. Arkowski, K. Początek and W. Mazurek



Multi-detector Computed Tomography

Multi-Detector Computed Tomography of the Coronary Arteries – New Clinical Applications
D.A. Halon, T. Gaspar, N. Peled, R. Rubinshtein and BS. Lewis

Cardiac CT for evaluating Chest Pain in the Emergency Department
Vassilios Raptopoulos

64-slice Computed Tomography-Facilitated Percutaneous Coronary Intervention for Chronic Total Occlusion
H. Kaneda, T. Shiono, S. Tanaka, Y. Miyashita, S. Takahashi, Y. Taketani, H. Koga, J. Matsumi, H. Domae, S. Mizuno, Y. Minami, K. Sugitatsu, H.H. Ye and S. Saito

Electrophysiology and Electrocardiography
ECG Attenuation, and the Repercussions for Patients with Coronary Artery Disease
J. Madias

RR Interval Histograms and Heart Rate Variability in Early Recurrence of Atrial Fibrillation After Cardioversion
R. Vaiciulyte

Heart Rate Variability in Patients with Atrial Fibrillation Accompany Hypertension and Ischemic Heart Disease After Conversion
R. Vaiciulyte

The Reduced Heart Rate Variability Is Associated with Subclinical Inflammation and Predisposes To Recurrences of Atrial Fibrillation
I.A. Vogiatzis, I.M. Vogiatzis, C. Mitroulas, M. Konstantinidou, A. Sideropoulos and V. Sachpekides



Drug Therapy

Enhancement of Coronary Arterial Constriction in Response to Hyperventilation by Continuous Dosing of Nitrates
K. Kanamasa

The Effects of Low Dose N-Acetylcysteine as An Additive to Cardioplegia in CABG Patients
H. Koksal, A. Rahman, O. Burma, A. Uysal, I. Akar, I. Halefoglu and M. Kemal Bayar

The Effects of Resveratrol on Myocardial Ischemia-Reperfusion Injury (Experimental Study)
G. Siraci, A. Rahman, O. Burma, I. Akar, A. Uysal, I.H. Ozercan and N. Ilhan

Preoperative Statin Use and Outcomes Following Cardiac Surgery
I. Ali and K. Buth

Impact of Preoperative Statin Use on Sepsis and Deep Sternal Wound Infection Following Cardiac Surgery
I. Ali and K. Buth

Red Clover Attenuates Aortic and Coronary Fatty Streak in Hypercholesterolemic Rabbits
S. Asgary, Gh. Naderi, J. Moshtaghian, Hosseini, G. Dashti and S. Adibi

The Role of Haemodialysis in the Management of Severe Right Heart Failure
D. Eleftheriadis, P. Vrizidis and N. Eleftheriadis

The Effect of Beta-Blocker Treatment on Heart Rate Variability in Female with Essential Hypertension
K. Kawecka-Jaszcz, D. Czarnecka, P.J. Thor, A. Pośnik-Urbańska, A. Furgała, T. Banach and W. Kolasińska-Kloch

Effects of NEBIVOLOL on Left Ventricular Function and Exercise Capacity in Patients with Non-ischemic Dilated Cardiomyopathy. A 12–Month Study
A.P. Patrianakos, F.I. Parthenakis, G.F. Diakakis, H.E. Mavrakis, M. Saatsaki, M. Homatidis and P.E.Vardas



Prognosis and Rehabilitation

Impact of Helicobacter Pylori on Prognosis of Acute Coronary Syndrome
R. Eskandarian, S. Mosavi, M. Babai, J. Tosi, R. Ghorbani, M. Malek, M. Shiasi, B. Momeni, A. Ghasemi, A. Vatani and M. Zahmatkesh

Osteoarticular Lesions Does Not Affect Benefits of Cardiac Rehabilitation
A. Gómez-González, A. Montiel-Trujillo, J.C. Bravo-Navas, M. Martínez- Lao, B. González-Jiménez, R. Aguilar-Jiménez, R. Collantes-Rivera, S. Espinosa (in memoriam)

Multidisciplinary Approach of Patients with Ischemic Heart Disease: Benefits of a Cardiac Rehabilitation Program
A. Montiel-Trujillo, A. Gómez-González, J.C. Bravo-Navas, M. Martínez-Lao, B. González-Jiménez, R. Aguilar-Jiménez, R. Collantes-Rivera and S. Espinosa-Caliani (in memoriam)

The Prognostic Value of the Blood Glucose Concentration in Acute Myocardial Infarction
I.A. Vogiatzis, I.M. Vogiatzis, C. Mitroulas, M. Konstantinidou, A. Sideropoulos, V. Sachpekides and A. Kandili



Ventricular Function and Heart Failure

The Importance of Coronary Artery Disease in Incident Cases of Heart Failure
G.C. Sutton

Improvement of Regional Myocardial Function Following Exercise Training in Patients With Left Ventricular Dysfunction
M. Deljanin Ilic, S. Ilic, B. Ilic, V. Stoickov and D. Petrovic

Ultrasonograph and Vectocardiograph Evaluation of Heart Insufficienty in Dilatative Cardiomyopathy
Z. Pekmezovic, M. Pekmezovic and Z. Nestorovic



Neurohormonal Aspects

C-type Natriuretic Peptide Plasma Levels and Chronic Heart Failure
S. Del Ry, M. Maltinti, C. Passino, M. Piacenti, M. Emdin and D. Giannessi

BNP as an Index of the Metabolic Activity in the Subendocardium of the Left Ventricle
N. Nranyan, M. Kemp, J. Hooper and D. Gibson



Interventional Cardiology

The Present and Future of Interventional Cardiology
B. Meier

Overview of Japanese Current Techniques for CTO Lesions
S. Saito

Long-term Follow-up Results from the Sirolimus-eluting Stent Clinical Trials
J.E. Sousa and A. Sousa

Target-Vessel Revascularization Among Patients Who Received Oral Rapamicyn or Placebo After Bare-Metal Stent Implantation. Eighteen-Month Clinical Follow-up of the RAPAMUNE Study
C. Cernigliaro, M. Sansa, A. Verde and E. Novelli

Coaxial Technique with Judkins-shaped Catheters for Coronary Angiography in Patients with Tortuous Iliac Arteries and Dilated Ascending Aorta
M. Iacob, F. Pinte, I. Tintoiu, V. Goleanu, G. Cristian, L. Cotuna, M. Coroiescu, S. Filip, I. Muscaliuc, V. Greere, G. Neagoe, L. Chiriac, R. Bolohan, P. Crisan, G. Hila, J. Roates, O. Lazar, V. Murgu, V. Arhire and E. Postolea

Assessment of Mortality in Patients Above 70 Years Old Treated for Myocardial Infarction in Two-year Follow-up
D. Kawecki, A. Tomasik, K. Zełobowska, K. Szczurek-Katański, W. Jacheć, M. Rykaczewska-Czerwińska, I. Świtalska-Janiczek and J. Wodniecki

Comparison of Efficacy and Safety Between Sirolimus-Eluting Stent (Cypher) and Paclitaxel-Eluting Stent (TAXUS) on the Outcome of Patients with Chronic Total Occlusions: Multicenter Registry in Asia
S. Nakamura, JH. Bae, Y. Cahyadi, W. Udayachalerm, D. Tresukosol and S. Tansuphaswadikul

Modified Implantation and Delivery Techniques of Coronary Stent Grafts: Side-Branch Occlusion Can Be Prevented
F. Pinte, M. Iacob, I. Tintoiu, V. Goleanu, G. Cristian, L. Cotuna, M. Coroiescu, S. Filip, I. Muscaliuc, V. Greere, G. Neagoe, L. Chiriac, R. Bolohan, P. Crisan, G. Hila, J. Roates, O. Lazar, V. Murgu, V. Arhire and E. Postolea

The Impact of Intracoronary Low Power Laser Irradiation After Coronary Angioplasty on Blood Concentration of Selected Growth Factors
A. Derkacz, M. Protasiewicz, R. Poreba, M. Negrusz-Kawecka, A. Skoczynska, M. Wawrzynska and W. Mazurek

First in Men Randomized Study on the Intracoronary Low Power Laser Irradiation in Restenosis Prevention
A. Derkacz, M. Protasiewicz, R. Poreba, M. Negrusz-Kawecka and W. Mazurek

Relation Between Ethanol Dose and Clinical Outcomes in Patients Undergoing Percutaneous Septal Ablation for Obstructive Hypertrophic Cardiomyopathy: A Prospective, Randomized Study
J. Veselka

Alcohol Septal Ablation for Hypertrophic Obstructive Cardiomyopathy Improves Myocardial Performance: A 24-month Follow-up
J. Veselka



Surgical Aspects

Impact of 19mm Prostheses on Survival After Aortic Valve Replacement
B. Goldman, N. Desai, M. Tarulli, G. Christakis, G. Cohen, J. Sever and S. Fremes

New Surgical Techniques in the Treatment of Ischemic Cardiomyopathy (MAGIC II Study)
J. Brickwedel, D.H. Boehm and H. Reichenspurner

Surgery for Ischemic Mitral Regurgitation: The Impact of Residual IMR on Late Survival
S. Silberman, A. Oren, M.W. Klutstein, E. Asher, O. Merin, D. Fink, M. Deeb and D. Bitran

Gene and Cell Therapy: Alternative Approach for Myocardial Revascularization
L.A. Bokeria, E.Z. Golukhova, M.V. Eremeeva and I.I. Berishvili

Surgical Patch Angioplasty of the Left Main Coronary Artery and/or the Proximal Segment of the Right Coronary Artery
M. Malyshev, I. Gladyshev, A. Safuanov, A. Malyshev, D. Siniukov, D. Borovikov, N. Rostovykh and V. Trushyna

Does Off-pump Coronary Artery Bypass Reduce the Incidence of Perioperative Stroke Among Patients with Cerebrovascular Occlusive Disease?
Y. Takahara and K. Mogi

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