New Trends in Alzheimer
and Parkinson Related Disorders: ADPD 2007
March 14-18, 2007, Salzburg,
This book contains 46 papers, written by self
selected authors, who had presented their research at the 8th
International Conference on Alzheimer’s and Parkinson’s Diseases
(AD/PD), that took place on March 14-18, 2007, in captivating Salzburg,
the birthplace of Wolfgang Amadeus Mozart. The official proceedings of
the Conference will be published early in 2008, as a special edition of
the journal Neurodegenerative Diseases (Karger).
The Salzburg Meeting included over 2,200 scientific
participants, the largest attendance ever in this series of AD/PD
Conferences. It served as a venue for a rich scientific experience
involving invited talks, general talks, posters, and symposia. It was
impractical to include all of the scientific information presented at
this meeting under one cover, while at the same time, meeting time
deadlines and publisher’s costs. We, the co-organizers, therefore chose
to restrict contributions to the official proceedings of the Conference,
to chapters written by invited speakers at the Conference.
This is the third time that Medimond has partnered
with us (earlier publications in this series were released in 2003 and
2005), to provide an outlet for many additional reports on excellent
research presented in Salzburg, that we were not able to include in the
official Proceedings, for the reasons mentioned above.
Medimond’s policy is to provide rapid publication of
conference proceedings. Therefore, we agreed with the publishers’
request that we would limit our editorial corrections specifically to
major errors in language, and/or scientific logic. We did not concern
ourselves with stylistic differences in expression by authors whose
first language is other than English, nor with editorial format, or
subject matter. Moreover, each author is solely responsible for the
information provided in his/her chapter, and the subject matter included
does not necessarily represent concurrence of the editors.
A more thorough and rigid editorial process will be
employed with the official proceedings document.
We would like to thank the authors of the chapters in
this book for their understanding and cooperation with our
topic-selection decision, and for going along with Medimond’s conditions
for publication. The important work of these authors, presented at AD/PD
2007, thus gets to be expressed as well, with rapidity and efficiency.
Israel Hanin (USA), Manfred Windisch (Austria),
Werner Poewe (Austria), and Abraham Fisher (Israel)
Neuronal Inclusion Protein TDP-43 Has No Primary
Genetic Role in FTD and ALSI. Gijselinck, K. Sleegers, S. Engelborghs,
W. Robberecht, J.-J. Martin, R. Vandenberghe, R. Sciot, B. Dermaut, D.
Goossens, J. van der Zee, T. De Pooter, J. Del-Favero, P. Santens, P. De
Jonghe, P.P. De Deyn, C. Van Broeckhoven and M. Cruts
Alzheimer Disease and Vascular Dementia Have Distinct
Genetic Profiles for APOE, A2M, & IL-1aE. Corder, M. Pirskanen, M. Hiltunen, S.
Helisalmi, A. Mannermaa, A. Koivisti, H. Soininen, M. Lehtovirta, P.
Hartikainen, K. Ropponen, R. Pirinen, J. Böhm and I. Alafuzoff
Differential Gene Expression and Memory Deficit in
Young and Middle-Aged Rats Induced by Bilateral Carotid Occlusion A.I. Bier, Y. Bogoch, M. Linial and M.
A Gene Expression Signature in Blood to Accurately
Detect Alzheimer’s DiseaseA. Lönneborg, B. Booij, N. Hagen, K.
Bårdsen, M. Jensen, L. Kristiansen, G. Feten, T. Lindahl, B. Winblad and
Cholesteryl Ester Transfer Protein (CETP) Gene and
Cholesterol Metabolism in DementiaL. Fernández-Novoa, R. Llovo, S. Seoane, L.
Corzo and R. Cacabelos
Novel Suppressors of Ab Neurotoxicity
P. Fernandez-Funez, J. Salinas, L. Nino-Rosales and D. Rincon-Limas
Impact of Human Neuronal ABC Transporters on
Cholesterol Efflux and Amyloid-Beta ProductionW.S. Kim, A.F. Hill and B. Garner
Effect of NGF Infusion on Different Types of Memory
in Young and Aged RatsG. Niewiadomska, A. Mietelska, M.
Mazurkiewicz, A. Gasiorowska and M. Baksalerska-Pazera
Cerebrolysin Protects Neurons Against Serum
Deprivation Induced ApoptosisB.O. Popescu, S. Abramovici, D.F. Muresanu
and O. Bãjenaru
Cerebrolysin Promotes Neurogenesis in an APP
Transgenic Mouse Model of Alzheimer’s DiseaseE. Rockenstein, M. Mante, A. Adame, L.
Crews, M. Hitzl and E. Masliah
Down-Regulation of Brain-Derived Neurotrophic Factor
by Oligomeric Amyloid as a Mechanism for Alzheimer-Associated
Dysfunction M. Fahnestock
The Helical C-terminal Domain of Human
Butyrylcholinesterase Attenuates b-Amyloid Fibril Formation In VitroS. Diamant, E. Podoly, T. Bruck, H. Wilgus,
S. Langerman and H. Soreq
Muscarinic Transmission Is Impaired in Young Adult
Transgenic APPswe/PS1dE9 Female MiceE. Machová, J. Jakubík, P. Michal, M.
Oksman, H. Iivonen, H. Tanila and V. Dolezal
Memory Deficit Induced by Chronic Inhibition of
Cytochrome Oxidase in Rats Results from Alteration in Hippocampal
Cholinergic TransmissionM. Weinstock, L. Luques and S. Shoham
Oxidative-Dependent Stimulation of G-Proteins in
Human Control and Alzheimer’s Disease Brain by V717G ("London") FAD
Mutant of APP714-723E. Karelson, J. Eriksson, N. Bogdanovic, V.
Jefremov and T. Land
ApoE4 in Mice Induces Age-Dependent Brain
Hypoperfusion, Neuronal, Glial and Microvascular Damage, and Cognitive
Impairment, which can be Prevented By Feeding Acetyl-L-Carnitine and
R-Lipoic AcidG. Aliev, J. Liu, K. Xu, M. Puchowicz, S.L.
Siedlak, J.C. Shenk, M.A. Smith, E. Gasimov, M.E. Obrenovich, K.
Fischbach, J. Koistinaho, J.C. LaManna, B.N. Ames and G. Perry
Inflammation Sensitive Proteins Effect on b-Amyloid
Aggregation and ToxicityS. Giunta, R. Galeazzi and L. Galeazzi
How b-Amyloid Proteins and Pro-Inflammatory Cytokines
Might Collaborate to Produce the "Alzheimer Brain"I. Dal Pra, A. Chiarini, R. Pacchiana, B.
Chakravarthy, J.F. Whitfield and U. Armato
Differential Apoptotic Response of Primary Human
Cerebral Endothelial Cells to Oligomeric Assemblies of Amyloid-Beta
Genetic VariantsJ.A. Cam, J.L. Meyerson, E. Mezhericher, J.
Ghiso and A. Rostagno
Development of Cost-Effective, Homogenous 384-Well
High Throughput Screening Assays for Ab1-42 and Ab1 40 Using Alphascreen™
TechnologyP. Szekeres, K. Leong and E. Karran
Crystal Structure of Amyloid Beta FragmentK. Takano, Y. Takeda, D.-J. You, A.
Mukaiyama, H. Matsumura, Y. Koga and S. Kanaya
Constitutive a-Secretase Activity of Alzheimer’s
Amyloid Precursor Protein by ADAM19, but not by ADAM12N. Hotoda, C. Tanabe, E. Futai, N. Sasagawa
and S. Ishiura
Plasmalogens and APP-Processing: Method for the
Analysis of Altered Plasmalogen HomeostasisM.O.W. Grimm, J. Kuchenbecker, E.G. Zinser
and T. Hartmann
Cu(II)-Catalyzed Formation of Plastic Composites in
ADP.S. Willsie, C.K. Harris and N.W. Seidler
Oligomeric a-Synuclein Affects Kinase Activities as
Revealed by High-Density Kinome ArraysC. Schnack, K. Danzer, A. Suttcliffe, B.
Hengerer and F. Gillardon
Nitric Oxide and Aminopeptidase A Are Inversely
Correlated in Plasma of Experimental HemiparkinsonismI. Banegas, I. Prieto, F. Vives, F. Alba,
A.B. Segarra, R. Wangensteen, F. Hermoso, R. Duran and M. Ramírez
Role of SIRT1 in the Neuroprotective Effects of
Resveratrol on MPP+-Induced Apoptosis in Neurons D. Alvira, M. Yeste-Velasco, J. Folch, E.
Verdaguer, V. Rimbau, A.M. Canudas, M. Pallàs and A. Camins
The Effect of L-2-Amino-4-Phosphonobutyrate, A
Presynaptic Glutamate Receptor Agonist on Motor Disorders Induced by
6-Hydroxy-DopamineM. Qazzaz, R.M. Husein, M. Metani and A-S.
Neuroprotective Role of Heme Oxygenase-2 in 6
Hydroxydopamine-Lesioned MouseY-S. Kim, D. Guastella, M. Ahmad and S.
Coexistence of Neurotransmitters in Parkinson’s
DiseaseA.A. Qureshi, G.A. Qureshi and S.H.Parvez
Alpha Synuclein Oligomers – The Toxic Species in
Parkinson’s Disease?K.M. Danzer, A.R. Karow, B. Hengerer and M.
EEG Comparisons in Early AD, DLB, PDD Patients with a
2 Years Follow-upL. Bonanni, A. Thomas, D. Monaco, F.
Baldassarre and M. Onofrj
The Influence of Co-Morbidity Factors in a MCI Risk
Sample and Their Influence on the MCI-Alzheimer’s Dementia ConversionL. Spiru, I. Ioancio and C. Ghita
CSF Tau Proteins in Evaluation of Patients with
Suspected DementiaG. Simic, M. Boban, H. Sarac, K. Grbic,
P.R. Hof, C. Hamann, N. Ackl, B. Bader and A. Danek
Alzheimer’s Disease - Safety and Dropout in Long-Term
Galantamine Treatment in a Routine Clinical SettingÅ.K. Wallin, C. Wattmo and L. Minthon
Activities of Daily Living – Outcome During Two Years
in Galantamine Treated Alzheimer PatientsC. Wattmo, Å.K. Wallin and L. Minthon
Neuropsychological Aspects of Cognitive Impairments
Associated with Body ImbalanceK. Sakamoto, C. Nakayashiki, M. Hida, F.
Sakamoto and N. Ishiko
Stance Adaptation to Unilateral Achilles Tendon
Vibration in Parkinson’s Disease and Vascular Dementia PatientsM. Saling and P. Valkoviè
Duodenal Enterocyte Mitochondrial Involvement and
Abnormal Bowel Function in Idiopathic ParkinsonismD. Ellis, R.J. Dobbs, S. Dobbs, A. Curry,
I. Bjarnason, J. Williams, M. Mccrossan, C. Weller and A. Charlett
A Direct, or Surrogate, not Necessarily Unique, Role
for Helicobacter Infection in Pathogenesis of Idiopathic Parkinsonism:
Analogy and Contrast with Gastric CancerS.M. Dobbs, R.J. Dobbs, A. Charlett, C.
Weller, I.T. Bjarnason, A. Price and N. Oxlade
Which Neuropsychological Investigation in Amnesic
Mild Cognitive Impairment?L. Paciaroni, S. Paolini, M. Guidi and O.
Colostrinin™ Increases the Lifespan and Neurological
Performance of MiceI. Boldogh, A. Bacsi, L. Agulera-Aguirre,
P. German and M. Kruzel
Therapeutic Potential of Potent Marine
NeuroprotectansE. García-Palomero, P. Usán, J. Pérez-Baz,
R.I. Fernández, A. Martínez, A. Fernández and M. Medina
Imperacer™ - New Prospects in CNS Biomarker DetectionR. Wacker
Dementology – Solution for the FutureJ. Reban
Vascular Risk Factors and Endothelial NOS3
Polymorphic Variants in Alzheimer’s DiseaseL. Corzo, L. Fernandez-Novoa, S. Rodriguez
and R. Cacabelos