8th World Congress for
(August 15-19, 2007
Milwaukee, Wisconsin, USA)
The microcirculation consists of the smallest blood
vessels that have a vital role in maintaining the normal function of all
the organs of the body by supplying oxygen and nutrients and removing
waste products. In addition, the ability of the microcirculation to grow
new blood vessels is crucial in allowing the recovery of vital organs
following disastrous events such as stroke and heart attack. Because of
its strategic location and importance in maintaining normal organ
function, the microcirculation is crucial in both the development and
the treatment of many diseases. For example, microvascular dysfunction
plays a pivotal role in the organ damage and other pathological
consequences of diabetes. Impaired function of the small arteries
immediately upstream from the microcirculation is a major factor
contributing to the elevated vascular resistance that is a common
denominator in virtually all forms of hypertension. In addition,
abnormal function and/or loss of the smaller arterioles and capillaries
(microvascular rarefaction) not only contributes to elevated vascular
resistance in hypertension, but may be even more important in
jeopardizing tissue perfusion and organ function under conditions of
circulatory stress in hypertensive individuals. Breakdown of normal
microcirculatory function also plays a crucial role triggering the
multiple organ failure that eventually leads to irreversible shock and
circulatory collapse in trauma and infection. Finally, the
microcirculation is the pathway by which various forms of cancer spread
throughout the body from their point of origin. As such, a variety of
therapeutic approaches have been developed that are designed to prevent
the development of microvessels in tumors, in order to prevent their
growth and metastasis.
research has been a fertile developing ground for highly advanced
methodology to study vascular regulation, tissue oxygenation, and blood
flow in small vessels. Another strong historical component of
microcirculatory research has been the application of sophisticated
techniques of mathematical modeling to understand microvascular function.
In this respect, the computational biology approaches that are becoming
increasingly popular in a variety of different fields of biology and
medicine have been a major factor in increasing our understanding of
microvascular function, and continue to prove their usefulness. In
recent times, microcirculatory research has embraced modern techniques
of cell and molecular biology, systems biology, and physiological
genomics in order to increase our understanding of the vital role of the
microcirculation in maintaining normal physiological function. The
combination of these newly emerging techniques with the sophisticated
methodological and computational approaches and whole-animal integrative
approaches that have formed the backbone of classical microcirculatory
research provide a powerful and integrated understanding of
physiological function that is impossible to obtain with approaches
employing cellular and molecular biological techniques in isolation.
The 8th World Congress for
Microcirculation attracted delegates from 6 continents and 30 countries
to Milwaukee, Wisconsin to share their knowledge on new methodologies,
experimental models, and instrumentation that is used to investigate the
function of the microcirculation in health and disease; and to report
the latest scientific findings relevant to the function of the
microcirculation in health and disease. Sixteen different
microcirculatory societies from throughout the World contributed to the
scientific content of the 8th World Congress, providing an unparalleled
opportunity to foster communication among microcirculatory researchers
and between microcirculatory researchers and investigators in other
areas of vascular biology. The World Congress also provided an
opportunity to foster communication between physicians and basic
scientists regarding the importance of the microcirculation in various
diseases and to promote an increased understanding of the role of the
microcirculation as a therapeutic target for the treatment of disease.
The contents of this volume provide a sampling of microvascular research
in many of the crucial areas of vascular research mentioned above,
including vascular structure and development, vascular regulation,
computational biology of the microcirculation, and translational
physiology of the microcirculation. The inescapable conclusion from the
scientific presentations and interactions at the 8th World Congress for
Microcirculation is that microvascular research, in all its forms, will
remain a powerful tool for understanding normal physiological function
and a wide variety of disease processes, and that this area of research
will continue to be an exciting and rewarding field of study for young
investigators and established scientists alike.
Julian H. Lombard, Ph.D.
Chair-8th World Congress for Microcirculation
Department of Physiology
Medical College of Wisconsin
8701 Watertown Plank Rd.
Milwaukee, WI 53226 USA
Vascular Biology of the Microcirculation
Reactive Oxygen Species and Altered Cell Signaling in
Voltage-Dependent Calcium Channels in Renal
Resistance Vessels P.B. Hansen, B.L. Jensen, U.G. Friis, D.
Andreasen, T.R. Uhrenholt and O. Skřtt
Role of Ca Channel Subtype in the Renal
Microcirculation with Special References to Kidney InjuryK. Hayashi, S. Wakino, K. Homma, N. Sugano
and H. Itoh
Discovery and Significance of Shear Stress Dependent
Regulation of Vascular ResistanceA. Koller and G. Kaley
Buffering Effects of Nitric Oxide on Low-Frequency
Variability in Arterial Pressure OscillationsN. Iida and S. Ryumae
Differential Expression of bFGF in Brain and Cardiac
Capillary Endothelial CellsS. Lecht, C. Förster, I. Krilovetzky, C.
Marcinkiewicz P.I. Lelkes and P. Lazarovici
Age-Related Alterations in nNOS-Dependent Reactivity
of Cerebral ArteriolesD. Arrick and W. Mayhan
Covalent Complex of eNOS In Vivo Y. Chen, M.A. Raza, M. Medhora and E.R.
Changes in Skin Microcirculatory Dynamics by
Percutaneous Application of Carbon DioxideY. Nagashima, H. Mori, M. Suzuki, H.
Yokomichi, Y. Yada, S. Tsuchiya, T. Suzuki, K. Sasaki and S. Oh-ishi
Morphology of Sympathetic t-PA TransportZ. Hao, X. Jiang, R.E. Cone, S. Dufour and
Computational Biology of the Microcirculation
Multiscale Modeling of Cardiac Cellular EnergeticsJ.B. Bassingthwaighte and B.E. Carlson
Simulation of Blood Glucose Regulation and
Anti-Diabetic Drug Action In Vivo: The Kobe ModelM. Fukushima, Y. Sunaga, Z. Shu, Y.
Kawahara and S. Seino
Phosphofructokinase Is Critical for Hypoxia-Induced
Activation of Glycolysis in Human Erythrocytes: Prediction by
Biosimulation and Verification by Metabolome AnalysisA. Kinoshita, K. Tsukada, T. Soga, T.
Hishiki, M. Tomita and M. Suematsu
Modeling for Neural Control of Cardiac Excitation I. Findlay, S. Suzuki, S. Murakami and Y.
A Computational Model of Biochemical Interaction of
NO and Reactive Oxygen Species in the Microcirculation M. Kavdia and W.J. Richardson
Vascular Structure and Remodeling
Cellular and Molecular Mechanisms of ArterializationJ.I. Pagel, M.H. Maurer, U. Pohl and E.
Carotid Plaques from Symptomatic Stroke Patients Show
Upregulated Angiogenic Gene Expression R.J. Dempsey, K. Türeyen, S. Salamat and R.
Disruption of Coordinated Angiogenesis and Cardiac
Hypertrophy Contributes to the Transition to Heart FailureY. Izumiya, I. Shiojima and K. Walsh
Vascular Smooth Muscle Cell Plasticity and Vascular
RemodelingL.A. Martinez-Lemus, G.A. Meininger and
Extracellular Matrix-Mediated Tube Formation From
Isolated Hepatic Sinusoidal Endothelial Cells-Involvement of Rho GTPases
and caveolae M. Oda and H. Yokomori
Stiffness of the Extracellular Matrix Has Opposite
Effects on Angiogenesis and Vasculogenesis In Vitro N.I. Ervin, S. Uriel, M. Moya, M.L. Morley
and E.M. Brey
Development of In Vivo Model with Total Skin Flap
Chamber for Visualizing Vascular Network RemodelingN. Ohura, I. Shiokawa, A. Takushima, S.
Ichioka, M. Shibata and K. Harii
Acute Stretch Promotes Vascular Growth in Wounded
Healing Mouse Skin F. Reilly, C. Shrader, H. Ressetar, J. Luo
and E. Cilento
Translational Physiology of the Microcirculation
Paracrine Regulation of Arterial Tone by ADRF in
Obesity-Associated Hypertension in NZO MiceM. Gollasch, G. Fésüs, G. Dubrovska, K.
Gorzelniak, R. Kluge and F.C. Luft
Naringenin Exerts Its Anti-Tumor Effect Via
AntiangiogenesisF. Zhang, G. Du and W. Liang
Genetic Determinants of Vascular Oxidant Stress: A
Key Role for Glucose-6-phosphate DehydrogenaseJ. Loscalzo and J.A. Leopold
Vascular Resistance Induced by Oxidized Red Blood
Cells with Enhanced Adherence to EndotheliumA. Koshkaryev, D.K. Kaul, G. Barshtein and
Role of TNF alpha in Prediabetic Metabolic Syndrome
Induced Endothelial DysfunctionX. Gao, Y. Park, S. Capobianco, J. Yang, H.
Zhang, A. Picchi and C. Zhang
Morphological Peculiarities of Heart and Coronory
Vessels Damage in Adults with Type 2 Diabetes MellitusE. Sokolov and A. Davydov
Rescue of Hypoxia/Reoxygenation Induced Impaired
Dilation in Rat Cerebral ArteriolesH.H. Dietrich, C. Xiang and R.G. Dacey, Jr.
In-vivo Visualisation of Microvascular Endothelium
(In)Dependent Reactivity in ManP. van der Baan, P. de Leeuw, C. Stehouwer
and A. Houben
Does All Peripheral Microcirculation Coherently
Derived by the Heart Pumping? M.Y. Jan, T.L. Hsu, P.T. Chao, S.P. Li,
W.K. Wang and Y.Y. Lin Wang
D-4F Does Not Mitigate Key Parameters in Rat Model of
Severe Pulmonary HypertensionR. Molthen, S. Baumgardt, and K.A.
Regular Physical Training Improves Microvascular
Reactivity in Hypertensive PatientsL. Pasqualini, G. Schillaci, G. Pucci, S.
Innocente, D. Siepi, F. Coscia, S. Simonetti, B.P.R. Kouadio, M.V.
Amoruso, M.F. Cacioni and E. Mannarino
Raman Micro-Spectroscopy Measurement of Hemoglobin
Oxygen Saturation Using 532 nm Excitation I. Torres Filho, R. Filler, E. Proffitt, L.
Torres, J. Terner, R. Pittman and K. Ward
Tissue Oxygenation of Human Mucosa Using Resonance
Raman SpectroscopyI. Torres Filho, J. Terner, L. Torres, D.
Vakhshoori, P. Wang, K. Knopp and K. Ward
Pulmonary Microvascular Injury Resulting from a
Single Exposure to Low-Dose Thoracic RadiationQ. Wu, G. Schmirler, J.E. Moulder, E.R.
Jacobs, M. Medhora and R. Molthen
Assessment of Rat Renal Perfusion Using Infrared
ImagingA.M. Gorbach, H. Wang, D. Marsh and N.