Congress In Vitro Fertilization & 3rd World Congress In Vitro Maturation
15-19, 2007, Montreal,
In 1978, when
Louise Brown entered the world as the first IVF baby, the field of
reproductive medicine was also in its infancy. However, along with
Louise, assisted reproductive technology has grown and blossomed over
the years, taking new and exciting directions, developing improved
techniques and making remarkable discoveries in the complexity of human
The 14th World Congress on IVF, held
in Montreal in September 2007, attracted an impressive faculty of
world-renowned speakers whose presentations were reflective of the
burgeoning field of reproductive medicine. Each of these speakers was
asked to share their knowledge and expertise beyond the confines of the
lecture hall by contributing a chapter to this volume. Together, they
present a state of the art overview of assisted reproductive medicine.
Broadly, this book covers clinical,
surgical and research topics including:
– Assisted reproductive technology –
– Clinical aspects of IVF
– IVM and oocyte quality assessment
– Male infertility
– Fertility preservation
– Reproductive Surgery
– Outcome of assisted reproductive
However, in the heady onward rush of
scientific discovery, it must not be forgotten that reproductive
technology goes beyond medicine and research – it affects the human
psyche on the deepest, most fundamental levels and has given rise to
moral, psychological and social issues that have never before confronted
humanity. Ethicists, psychologists and patient advocates must therefore
share the podium and, in this volume, they discuss:
– the psychological aspects of
– the ethical and legal aspects of
We sincerely hope that in reading this
book, you will gain new knowledge and insights into the exciting and
dynamic field of reproductive medicine. However, despite the many
advances in reproductive technologies, we must always bear in mind that
one goal remains constant: to help our patients achieve their dream of
giving birth to a healthy child.
We now return to Louise Brown: The
baby who started it all is now a beautiful young woman who recently gave
birth to a naturally-conceived child of her own. Since she entered the
world, several million IVF babies have been born – all within 29 short
years. It has been a remarkable journey so far but the most exciting
path still lies ahead, because all technologies are interim and we can
look forward to future breakthroughs.
Seang Lin Tan, Victor Gomel,
Roger Gosden, Togas Tulandi
Chapter 1: ART-Ovarian
Does the Hormonal Pretreatment Before the Controlled
Ovarian Hyperstimulation Improve the Clinical Success Rate of the
Duration of Pituitary Desensitisation of GnRH
Analogues: Effect on IVF Outcome D. Carone
The Use of rLH in Slow Responders to rFSHC. Alviggi, R. Clarizia, I. Strina, M.
D’Uva, M.T. Varricchio and G. De Placido
Ovulation Induction with Urinary FSH or Recombinant
FSH in Polycystic Ovary Syndrome Patients Undergoing to IVF: A
Prospective Randomized Analysis of Results and Cost-EffectivenessD. Carone and R. Chiappetta
An Alternative to Decrease IVF Costs. First Twin
Pregnancy in Mexico with FSH/hCG Protocol for Controlled Ovarian
HyperstimulationS. Cuneo, S. Cubillos, E. Arreola, I.
Maldonado, S. Sánchez, E. Obregon and A. Bermúdez
Chapter 2: Clinical aspects
of in-vitro fertilization (IVF)
Day 3 or Day 5 Embryo TransferXingqi Zhang
Treatment of Implantation FailureT. Mori
Egg Donation Program: The Spanish ExperienceR. Aurell and E. Clua
15 Years Experience in Oocyte Donation Using
Split-Cycle DonorsG.R. Lipowicz
The Effect of Source of Eggs (Infertile Donor Vs.
Paid Recipient), Age of Donor, and History of a Previous Pregnancy on
Pregnancy and Implantation Rates In RecipientsJ.H. Check, K. Iacone, J.K. Choe, C.
Wilson, D. Brasile and J. Amui
Study on the Outcome of Transfer of Frozen-Thawed
Embryos in Artificially Prepared Cycles with or without Prior
Gonadotrophin Releasing Hormone Agonist TreatmentA. Kaluarachchi, S. Wijeratne, C. Nelson,
L.M.C. Nishantha, S. Wijemanne and H.R. Senevirathne
Importance of Color Doppler Evaluation in Assisted
Abnormal Cervical Cytology in Infertile Women
Eligible for IVF/ETN. Smiljan Severinski, O. Mamula, M.
and D. Vrdoljak Mozetiè
Conventional TechniquesSelahittin Çayan
Chapter 3: In-vitro
maturation (IVM) and oocyte quality assessment
Factors Predicting the Success of In-vitro Maturation
(IVM)S.E. Elizur and S.L. Tan
IVM of Immature Oocytes Derived from Women with PCOY. Morimoto
Cumulus Glycodelin and Its Possible Impact on Oocyte
MaturityN. Gneist, G. Keck, I. Trinkaus, B. Heiss,
B. Thieme, K. Hänseroth and W. Distler
FSH-Receptor Expression in Human Cumulus Cells of
Individually Denuded OocytesN. Gneist, G. Keck, I. Trinkaus, B. Heiss,
B. Thieme, K. Hänseroth and W. Distler
TAF4B Is a Molecular Marker of Oocyte QualityC. Di Pietro, M. Vento, M. Ragusa, D.
Barbagallo, M.R. Guglielmino, T. Maniscalchi, L.R. Duro, L. Tomasello,
P. Borzì, P. Scollo and M. Purrello
Chapter 4: Male infertility
Evaluation of Male InfertilityT.F. Kruger
Cytogenetics and Male InfertilityR.H. Martin
ART in Azoospermia and Aspermia B. Zorn
Evidence that Intracytoplasmic Sperm Injection (ICSI)
May Produce Embryos Less Likely to ImplantJ.H. Check, D. Summers-Chase, J.K. Choe, J.
Amui and D. Brasile
How to Study and Select the Best Sperm for ICSIG. Ruvolo
Sperm Chromatin as a Target for Male Mediated
Developmental ToxicityB. Robaire and B.F. Hales
Sperm and Embryonic Stem CellsToshiaki Noce
Chapter 5: Fertility
Assisted Reproduction and Breast CancerK. Oktay
Preservation of Fertility with Cryopreservation and
TransplantationS.J. Silber, D. Levine, J.A. Pineda, M.
DeRosa, K. Lenahan, K.S. Gorman and R.G. Gosden
Oocyte Morphological Quality Has No Impact in the
Survival Rates After Vitrification and Thawing by Cryotop MethodI. Maldonado, S. Cubillos, A. Bermúdez and
Blastocyst Cryopreservation by VitrificationJ. Liebermann
Chapter 6: Embryology
New Developments in Human Embryo CultureJ. Cohen, J. Biggers, M. Cecchi, D. Rieger,
T. Schimmel and K. Wiemer
Estimation of Respiratory Activity of Individual
Human Embryos by Scanning Electrochemical MicroscopyH. Abe, M. Yokoo, T. Itoh-Sasaki, M. Nasu,
K. Goto, Y. Kumasako, Y. Araki, H. Shiku, T. Matsue and T. Utsunomiya
Elevated Systemic Insulin and Compromised Embryonic
Developmental CompetenceG.D. Smith
The Use of Lasers in Art: Does It Help?T. Gurgan, S. Guven and A. Demirol
Excess Residual Cytoplasm Affect Spermatozoa Survival
After Sperm Selection ProcedureN. Chakroun Feki, N. Abid, C. Chaari, A.
Sallemi, B. Ben Ayed, C. Kalle, M. Guermazi, A. Bahloul, T. Rebai and L.
The Impact of Sperm Incubation on the Chromatin
Condensation, DNA Strand Breaks and their Effect on ICSI OutcomeHammadeh M.E., Deryal., Sobek A., Dostert
T., Alexidis F.I., Schmidt W.
Correlation Between Reactive Oxygen Species (ROS),
Total Antioxidant (TAS) Concentration of Seminal Plasma and their Effect
on Spermatozoa Quality and IVF/ ICSI OutcomeM.E. Hammadeh, A. Sobek, F.I. Alexidis, W.
Schmidt, and M. Deryal
PGD by Polar Body Biopsy A.G. Schmutzler
Chapter 7: Reproductive
Endometriomas: Should this Be Removed Before In Vitro
Outcome of In Vitro Fertilization in Patients with
Advanced Endometriosis; Role of EndometriomaE. Diaz, R. Pommer, H. Sovino, P. Cespedes,
A. Fuentes, B. Arguello, A. Espinoza and L. Devoto
Uterus and IVF Controversies: Laparoscopic MyomectomyJ.B. Dubuisson and W. Parker
The Role of Hysteroscopy in Failed IVF CyclesHakan Yarali, Gürkan Bozdag and Ibrahim
Optimization and Evaluation of the Uterine Cavity for
Uterine Contractility and Assisted Reproductive
Treatments (ART)D. de Ziegler, T. Fraisse, M. Bellavia, S.
Colamaria, I. Streuli and G. de Candolle
Hysteroscopic Sub Endometrial Embryo Delivery (SEED)M.M. Kamrava and J.L. Hall
Chapter 8: Outcome of ART
First Mexican Pregnancy with Hatched Vitrified
Blastocyst from a Woman with Polycystic Ovary Syndrome as a Tool to
Avoid Multiple Pregnancy and Hyperestimulation Ovarian SyndromeS. Cubillos, I. Maldonado, A. Bermúdez, E.
Obregón and S. Cuneo
Twins In Art Is a Desirable Outcome: The "Pro"
Sonography of Multiple PregnanciesS. Warsof
Complications of Assisted Reproductive TechnologyG.I. Serour
Ovarian Hyperstimulation SyndromeProphylaxis and
Management S. El- Sahwi
Improving Outcomes in Multiple Pregnancies By Fetal
ReducitonM.I. Evans and D.W. Britt
Aspirin, Heparin and Immunotherapy for Recurrent
Pregnancy LossC.B. Coulam
Chapter 9: Psychological
aspects of infertility treatment
Stress and How It Relates to IVFJ. Boivin
Psychological Complexities Surrounding Ending IVF
Perceived Stress in Couples for IVFL. Arranz, F. Gavino, J. Ruiz, W. Aguirre,
D. Moreno, A. Velasco, J. Cedillo, Z. Sondon and S. Gavino
A Study on the Prevalence of Depressive Symptoms in
Infertile Couples Undergoing Invitro Fertilization and Embryo TransferA. Kaluarachchi, S. Wijeratne, D.
Lankeshwara, L.M.C. Nishantha, C. Nelson, S. Wijemanne and H.R.
Psychosocial Aspects of Multi-fetal Pregnancy
Chapter 10: Ethical and legal
aspects of reproductive medicine
Sex – Pre –SelectionJ.G. Schenker
From Homo Sapiens to Techno Sapiens: Children’s Human
Rights to Natural Human OriginsM. Somerville
Getting Government to Fund IVF. . .The Canadian
Therapeutic Application of Cord Blood Stem CellsC. Chillik
Minimal Ovarian StimulationW.L. Ledger
Slow Oocyte FreezingE. Porcu, T. Valdinoci, P.M. Ciotti, G.
Damiano, L. Cipriani, S. Taraborrelli, A. Bazzocchi, S. Di Ciaccio, A.
Farina, V. Mille and S. Venturoli