International Congress on Coronary Artery Disease – ICCAD 2007
(October 7-10, 2007, Venice, Italy)
Coronary artery disease remains a major challenge to the
medical profession. Although a concerted global effort has advanced and
transformed our understanding in many of the concepts related to
diagnosis and treatment of the disease, we have generated a new series
of crucial questions which need answers if we are to progress further in
our battle against disease. These issues relate to basic research and
the possibilities offered by cell therapy and myocardial regeneration,
to cardiac diagnosis and the role of revolutionary imaging technologies,
and to pharmacologic, interventional and surgical therapies, where we
are in the midst of major debates regarding the advantages and
disadvantages of the newer and older therapeutic options.
This volume is based on material
presented at ICCAD 2007 – the 7th International Congress on Coronary
Artery Disease, held in the wonderful city of Venice, Italy, on October
7-10, 2007. We thank most sincerely the faculty and participants who
spent long hours preparing presentations for the Congress and also these
chapters for publication. Thanks are also due to the pharmaceutical and
manufacturing industry, whose generous support made the Congress
possible, to Kenes International Congress Organizers, and to our
colleagues, friends and families for their never-ending help, support
and advice in planning the meeting. We hope and trust that the
discussions in Venice and these chapters, published so beautifully and
efficiently by Medimond, will help us all in planning the directions we
should be taking in our research and in patient management in the coming
Basil S. Lewis Venice, Italy,
David A. Halon
Moshe Y. Flugelman
Angiogenesis, Gene Therapy, Cell Therapy
Cell Therapy of Ischemic Heart Disease: Hype and HopeP. Menasché
Stem Cell Therapy in Chronic Cardiac FailureCM. Schannwell, M. Brehm, T. Zeus, M.
Köstering, P. Wernet and B.E. Strauer
Erythropoietin Enhances the Angiogenic Potency of
Bone Marrow Stromal Cells in a Rat Model of Myocardial InfarctionFumin Zhang, Dingguo Zhang, Zhijian Yang,
Yuqing Zhang, Xiang Gao, Wenzhu Ma and Kejiang Cao
Percutanous Endocardial Cell Injection in Hibernating
Myocardium: Mesenchymal Vs. Mononuclear Bone Marrow Derived Stem Cells
K. Krause, K. Jaquet, C. Lange, C.
Schneider, S. Geidel, T. Zienkiewicz, B. Köktürk, A.R. Zander and K.-H.
Intracoronary Application of Autologous Bone Marrow-
Derived Stem- Cells in Patients After Myocardial InfarctionJ. Jorgova, I. Manukov, D. Trendafilova, O.
Litzanov, R. Kasabov, Deenichina,
C. Tcvetkovski, C. Botev, I. Tonev, M. Minchev, V. Hrischev and V.
Basic Research, Molecular Biology
Infectious Agents and Chronic Diseases: Further
Evidence for a Viral Role in Alzheimer’s Disease, and Possible
Implications for Atherosclerotic DiseaseR. Itzhaki and M. Wozniak
Heat Shock Protein 60 and Cardiovascular DiseaseA.A. Knowlton, L. Lin, S.-Chan Kim, Y. Wang
and N. Siebenborn
Novel G Protein-Coupled Receptor Signalling Pathways
in Cardiac HypertrophyF. Mayor Jr., C. García-Hoz, A.S. Tutor, M.
Herranz, M.T. Díaz-Meco, J. Moscat, P. Penela and C. Ribas
Nuclear Proteins Involved in Heart DiseaseA. Ludtke and H.H.-J. Schmidt
Myocardial Proteom Analysis with Fourier Transform
Mass Spectrometry Differentiates Coronary and Valvular Heart Diseases
D. Baykut, G. Baykut, M. Witt, F.
Mayer-Posner, M. Bergquist, J. Bergquist and H.R. Zerkowski
Diabetic Cardiomyopathy and Its Prevention by
MetallothioneinX.K. Li, Y. Tan and L. Cai
Isoprostanes May Mediate Vasospasm in Human Radial
Artery Following Coronary Artery By-Pass SurgeryL.J. Janssen
Valsartan-Induced Reversal of Post-Translational
Modifications of the Delta-Subunit of ATP Synthase and Remodeling During
Reperfused Myocardial InfarctionB.I. Jugdutt and G. Sawicki
Possible Involvement of Nitric Oxide in the
Suppression of the Release of Cellular ATP During Ischemia in Cultured
Cardiac MyocytesK. Kawahara, T. Hachiro, and D. Matsuyama
Whole Blood and Platelet Transcriptome and Proteome
Alteration in Patients Affected by First Acute Myocardial InfarctionM. Bellin, L. Nanni, A. Viganò, M. Vasso,
G. Vallanti, D. Vozzi, N. Cristell, D. Cianflone, C. Gelfi, A. Maseri
and G. Lanfranchi
Reconstitution of Hematopoiesis in Lethally
Irradiated Mice by Lentivirally Transduced Bone Marrow Progenitor CellsN. Radukhina, O. Ilyinskaya, T. Vlasik, T.
Arefieva, P. Rutkevich, A. Kozlov, I. Rybalkin, T. Gurskaya, V.
Shishkina, A. Shevelev and E. Tararak
The Effects of Pentoxifylline on the Myocardial
Inflammation and Ischemia-Reperfusion Injury During Cardiopulmonary
BypassH. Ustunsoy, M.C. Sivrikoz, M. Tarakcioglu,
K. Bakir, E. Guldur and M.A. Celkan
PAI-1-Induction in Experimental Septic Cardiomyoptahy
Is Associated with Reduced Norepinephrine Overflow from the HeartU. Schaefer, P. Linsel-Nitschke, D. Hecht
von Saldern, I. Stölting, R. Levi, H. Schunkert and T. Kurz
Atherosclerosis, Lipids and Lipoproteins
Macrophage Foam Cell Formation Mediated by
Receptor-Independent Macropinocytosis of LDLH.S. Kruth, C. Buono, S.W. Waldo and Y. Li
Statins and Antibiotics for Treatment of Chlamydia
Atherosclerosis LesionsA. Shor
Efficacy and Safety of Combination of Prescription
Omega-3 (Omacor®) Added to Stable Statin Therapy in Hypertriglyceridemic
Subjects: The COMBOS TrialM.H. Davidson, H. Bays, E.A. Stein, K.C.
Maki, R. Doyle, R. Shalwitz and C.M. Ballantyne
Failure to Detect Chlamydia pneumoniae by Polymerase
Chain Reaction in Patients with Acute Coronary SyndromesI. Burazor, A. Vojdani, M. Burazor, S.
Stefanovic, A. Stankovic, G. Cvetanovic and G. Grujic
Gene Expression of the Human Atherosclerotic Plaque
and Blood Pathological State CommunicationS. Cagnin, M. Biscuola, C. Patuzzo, E.
Trabetti, M. Iafrancesco, A. Forni, A. Mazzucco, P.F. Pignatti and G.
The Effect of Lipid Lowering Therapy on hs-CRP and
oxLDL in Untreated Mild Hypertensive Patients Z. Caparevic, N. Kostic, S. Ilic, S. Jelic,
M. Dekleva, B. Pencic and V. Celic
Comparative Progression of Atherosclerosis in ApoE-/-
Mice Exposed to Environmental Tobacco Smoke and Concentrated Ambient
ParticlesL. Chen, C. Quan, Q. Li, X. Jin, M. Zhong,
Q. Sun and S. Rajagopalan
Selected Markers of Inflammation and Endothelial
Dysfunction in Patients with Stable Coronary Artery Disease Treated with
PTCA with/without Stent ImplantationW. Kolasiñska-Kloch,
M. Kloch, R. Rajtar, A. Furga³a,
and A. Dembiñska-Kieæ
The 1527 Ala®Gly
Polymorphism in the ATP-Binding Cassette Transporter ABCA7 Is Associated
with Dyslipidemia and Metabolic Syndrome in Women – Results from the
MONICA/KORA Echocardiographic Substudy
P. Linsel-Nitschke, A. Götz, U.R. Schaefer,
W. Lieb, P. Bruse, A. Doering, H. Loewel, B. Mayer, H. Schunkert and J.
Two Common Polymorphisms in the PON1-Promotor Are
Associated with Both Paraoxonase Activity and Risk of Myocardial
InfarctionP. Linsel-Nitschke, S. Belz, H. Jansen, A.
Goetz, I. Braenne, P. Bruse, W. Lieb, I.R. König, B. Mayer, A. Doering,
T. Meitinger, C. Hengstenberg, A. Ziegler, H. Schunkert and J. Erdmann
Evaluation of Oxidized Low-Density Lipoprotein in the
Coronary Circulation of Patients with Coronary Artery Disease, and its
Association with Percutaneous Coronary InterventionM.M. Ramadan, M. Kodama, S. Hirono and Y.
Involvement of Oxidative Stress in Experimental
Atherosclerosis: Experimental Study with Agaricus Sylvaticus and
Antioxidant Vitamins SupplementationS. Percário, V.F. Odorizzi, D.R.S. Souza,
W.N. Ogawa, M.A.S. Pinhel and M.F. Godoy
Association Between Fatty Liver Disease and Carotid
Atherosclerosis in Patients with History of StrokeL. Poanta, A. Albu and C. Grosz
Pravastatin and Rosiglitazone May Attenuate Coronary
Artery Disease by Decreasing Interferon-g,
Tumor Necrosis Factor-a,
Interleukin-6, Macrophage Chemotactic Protein-1, C-Reactive Protein, and
L.G. Tan, S.A. Tan and L.S. Berk
LDL- and HLD-Cholesterol Optimization Using
Phytonutrient Combination TherapyP.J.E. Verdegem
Endothelial Function, Vascular Biology
Human Monocyte/Macrophages In Vitro Model for
Screening of Photodynamic Effects E.R. Andreeva, O.O. Udartseva, E.M. Tararak,
S.G. Kuzmin and I.N. Vozovikov
Improved Saphenous Vein Graft Patency in Coronary
Artery Bypass Patients: The Contribution of an Intact Vasa VasorumM. Dashwood, A. Loesch, D. Filbey, M.
Dreifaldt and D. Souza
Turbulent Blood Flow Plays an Essential Localizing
Role in the Development of Atherosclerotic Lesions in
Experimentally-Induced Hypercholesterolemia in RatsC.M. Prado, S.G. Ramos, É.C. Campos and
Epidemiology, Prevention and Prognosis
The Role of National Surveys in the Assessment of
Quality of Care of Patients with Acute Coronary SyndromeThe Example of
From Vulnerable Plaque and Patient to Vulnerable
PeriodM. Mosseri and G. Landesberg
How To Do Prevention in Immigrants: Does the Second
Generation Need Special Programs?A. Bader, H. Bezirkan and M. Hochleitner
Myocardial Infarction: The 25-Year Trends of
Morbidity, Mortality and Fatality Rate in Russia (WHO Programs "Register
of Acute Myocardial Infarction", "Monica")V. Gafarov
Integrating Multi Disciplinary Community Heart Health
Program with Family Physicians: An Innovative Model for Vascular HealthN. Giacomantonio and W. Firth
Correlation Between GISSI Risk Score Classes and
Major Cardiovascular Events in a Population of Patients with Prior
Myocardial InfarctionE. Salvetti, G. Giuliani, F. Spezia, L.
Russo, M. Sansoni and A. Zipoli
Inhibition of Renin Angiotensin Aldosterone
System,and Insulin-Like Growth Factor-1 Axis and Physical PerformanceM. Maggio, A. Artoni, F. Lauretani, S.
Bandinelli, G. Onder, M. Pahor, S.M. Ling, C. Ruggiero, G. Valenti, L.
Ferrucci and G.P. Ceda
Seasonal Variation in Mean Platelet Volume and Acute
Myocardial InfarctionAyhan Cosgun and Huseyin Oren
The Effects of an Exercise Intervention on
Cardiovascular Risk Factors in Postmenopausal Type 2 Diabetics J.C. Orri, C.J. Thompson and D.E. Sellmeyer
Study of Reversibility of the Metabolic Syndrome and
Insulin Resistance: The ANTIATERO-ALIM StudyS. Dragan, C. Socaciu, I. Gergen, S. Mancas,
S. Ursoniu, D. Velimirovici, G. Otiman and M. Rada
Nocturnal Oxyhaemoglobin Desaturation and Plasminogen
Activator Inhibitor Type-1B. Pencic, M. Dekleva, V. Celic, Z.
Caparevic, N. Kostiæ and A. Grdinic
Empirically Derived or Pre-Existing Model to Evaluate
Hospital Performance? Comparison Between the Italian CABG Model and the
EuroSCORE SystemS. Rosato, P. D’Errigo, F. Seccareccia, V.
Manno, G. Badoni, D. Fusco and C.A. Perucci
Clinical Presentation, Outcome and Therapy in
Patients with Acute Myocardial Infarction. Correlation with Demographic
Factors – A RO-STEMI Analysis ReportD.
Gh. Pamfil, D.D. Ionescu, C. Militaru, G.A. Dan, I. Daha, G.
Tatu-Chiþoiu, E. Nechita and RO-STEMI investigators
Erectile Dysfunction – Early Sign or Risk Factor for
Vascular Disease? D.
Gh. Pamfil and M. Rãdoi
Cardiovascular Risk in Diabetic Patients Determined
by a Newly Developed Questionnaire on Autonomic Regulation (aR) R. Zerm, M. Kroez, D. Cysarz, M. Frühwirth,
M. Moser, M. Jecht, C. Heckmann and M. Girke
New Diagnostic Techniques
In Vivo Plaque Characterization in AMI Patients by
IVUS-VHH.-P. Schultheiss, B. Witzenbichler and M.
Echogardiographic Diagnostic Markers for the
Discrimination of Ischemic from Dilated CardiomyopathyG. Papanagnou, A. Karanassios and A.
Right Ventricle Function in Athletes After Isometric
TestL. Stefani, G. Pedrizzetti, A. De Luca, B.
Cappelli, L. Toncelli, V. Di Tante, A. Moretti, L. Caselli, A. Ingarozza,
R. Mercuri, M. Gianassi, P. Manetti, M.C.R. Vono, S. Mastrodicasa and G.
Tissue Doppler Imaging in Hypertensive Patients with
Coronary Artery DiseaseA. Stevanovic and M. Dekleva
Cardiac CT and MRI
Coronary CT Angiography in the Diagnosis of Patients
with Acute Chest PainD.A. Halon, R. Rubinshtein, T. Gaspar, N.
Peled and B.S. Lewis
The Role of Cardiovascular Magnetic Resonance in
CardiomyopathyA. Grasso, R. O‘Hanlon and D.J. Pennell
Role of Cardiovascular Magnetic Resonance in the
Evaluation of Myocardial IschemiaN. António, P. Donato, P. Monteiro, B.
Graça, H. Rodrigues, L. Gonçalves, F. Caseiro-Alves and L.A. Providência
The "Natural" History of Stable AnginaG. Sutton
Markers of Endothelial Damage, Selected Inflammatory
Markers and Uric Acid in Patients Undergoing Percutaneous AngioplastyR. Rajtar, W. Kolasiñska-Kloch,
M. Kloch, D. Drobniak-Heldak and A. Dembiñska-Kieæ
Acute Coronary Syndromes, Acute Myocardial Infarction
Modification of the Infarct Size Limiting Effects of
Statins by Antiplatelet DrugsR. Merla, Y. Ye and Y. Birnbaum
Collagen and Ventricular Remodeling During Healing
After Reperfused Myocardial Infarction. New InsightsB.I. Jugdutt
Antiplatelet Treatment in Acute Coronary Syndromes
Where Do We Stand?M. Keltai
ST-Segment and T-Wave Analysis Helps Diagnose the
Successful Myocardial Reperfusion in Patients with Acute Myocardial
Myocardial Performance Index Is Predictive for
Extensive Remodeling but not for Global Left Ventricular Dysfunction
After First Myocardial InfarctionM. Dekleva, V. Celic, M. Colic, J. Suzic,
N. Radivojevic and M. Ristic
Causes of Death in Acute Myocardial Infarction – A
Pathological StudyG.S. Gheorghe, I.T. Nanea, A.W. Stefanescu,
I.M. Andrei and M. Nanea
Clinical Experience in Percutaneous Cardiopulmonary
Support for Critically Ill Patients with Ischemic Heart DiseaseA. Takahashi, K. Hayashida, S. Nakajima, N.
Taniguchi, M. Yano, Y. Takahashi and H. Yaku
Circulating Pro-inflammatory and Anti-inflammatory
Cytokines in Patients with Unstable Angina PectorisE.V. Shlyakhto, E.M. Nifontov, E.G.
Sergeeva and O.V. Galkina
NT-proBNP, T Troponin, C-Reactive Protein Correlation
in Patients with Unstable Angina and non ST Elevation Myocardial
InfarctionE. Craiu, C. Voiculet, M. Toringhibel, F.
Vizireanu, C. Chiriac and C. Ginghina
Circumferential Wall Tension Due to Hypertension
Plays a Pivotal Role in Aorta RemodelingC.M. Prado and M.A. Rossi
CT-Scan Assessment of Anatomic Relation Between Left
Atrial Posterior Wall and Esophagus, and Pulmonary Veins Isolation
Post-Procedural ConsequencesS. Tissier
Prescription Omega-3 Added to Stable Statin Therapy:
A Mechanistic Perspective C.M. Ballantyne, H. Bays, R. Shalwitz, R.T.
Doyle and M.H. Davidson
Pharmacokinetic Interaction Between Prescription
Omega-3-Acid Ethyl Esters (P-OM3) and Rosuvastatin in Healthy SubjectsD. Patel, J. Liu, R. Doyle, J. Johnson and
Inhibition of Nitrate Tolerance without Reducing
Vascular Response During Eccentric Dosing of Nitrates K. Kanamasa
Heat Shock Protein (Hsp) Antibody Titers Are Reduced
by Statin TherapyM.C. Guisasola, E. Dulin, M.M. Desco, M.J.
Sanchez and P. García-Barreno
Beta-Blockers and Hydrochlorothiazides in Patients
with Diabetes Mellitus and/or Hyperlipidemia: Not Always Bad News. An
Austrian SurveyS. Sock, S. Perl, K. Stoschitzky, J. Plank,
E. Kvas and R. Zweiker
Ventricular Function, Heart Failure
Systolic and Diastolic Heart Failure – What Are the
Acute Cardio-Betamodulation Enhances Left Ventricular
Performance: Comparison Between Oesophageal Doppler and Invasive
Pressure-Volume Derived IndexesJ.C. Grignola, L. Devera, G. Reta, J.P.
Bouchacourt, G. Amonte, H. Píriz and R. Muchada
Sleep Apnea Syndrome in Patients with Chronic Heart
FailureD. Kawecki, R. Rybczyk, W.
I. Kawecka, A. Tomasik, C. Wojciechowska, G. Irlik, K. Mrówka-Kata, I.
E. Nowalany-Kozielska, G. Namys³owski
and J. Wodniecki
Left Ventricular Diastolic Function After AMI
Predicts Left Ventricular Expansion in Patients with Modestly Reserved
Left Ventricular Systolic FunctionS. Okino, F. Shigeru, J. Sugioka, A. Ikeda,
J. Maekawa, S. Ichikawa, M. Inagaki and S. Ozawa
Primary Angioplasty: One Month Mortality in Elderly
PatientsF. Bonechi, F. Calabrò, A. Naldoni, G.
Giuliani, A. Taiti, M. Nieri, E. Salvetti, F. Nassi and A. Zipoli
New Concept for Chronic Total Occlusion Using
Retrograde Approach via the Septal Branch in the RCAN. Ozawa, M. Shinozaki, T. Sato, T. Shimizu,
T. Miyauchi and T. Nagao
Coronary Plaque Composition of Culprit Lesions
Assessed by Virtual Histology Intravascular Ultrasound in Acute Coronary
Syndrome and Stable Angina T. Okado, H. Takase, T. Toriyama, S. Tanaka,
Y. Dohi and G. Kimura
Elective Day Case Transradial Percutaneous Coronary
Intervention – A 4 Year Single Centre StudyA. Wiper, R. Anantharaman, E. Mckay, C.
Appleby, J. MacDonald, S. Kumar, S. Eccleshall and D.H. Roberts
18-Month Outcome After Percutaneous Intervention in
Post-Coronary Artery Bypass Graft PatientsJ. Garcia-Tejada, M. Velazquez, F.
Hernandez, A. Albarran, J. Andreu, I. Gomez and J. Tascon
Novel Technique for Chronic Total Occlusion-Clinical
Experience in 0.010 Inch Guide Wire with Compatible Balloon Catheter
SystemM. Yano, A. Takahashi, N. Taniguchi, K.
Sato and S. Nakajima
Stents and Drug Eluting Stents
Efficacy of Drug-Eluting Stents in the Treatment of
Coronary Artery Bypass Graft LesionsJ. Garcia-Tejada, F. Hernandez, M.
Velazquez, A. Albarran, J. Andreu, I. Gomez and J. Tascon
Drug-Eluting Stents in Primary PCI: Health District
(Azienda Sanitaria Locale – ASL) 11, Tuscany, Italy Experience F. Bonechi, A.Taiti, M. Nieri, G. Giuliani,
F. Calabrò, F. Nassi, A. Naldoni and A. Zipoli
A Single Centre Experience of Left Main-Stem
Angioplasty Using the Endeavor™ StentK. Hertting, P. Burchardt, M. Hoffmann-Riem,
A. Mandel, W. Raut and C. Pott
Treatment of Drug Eluting Stents Restenosis. Single
Centre ExperienceS. Moreno-Reviriego, J. Lacunza-Ruiz, MJ.
Oliva-Sandoval, JR. Gimeno-Blanes, E. Pinar-Bermudez, R. Valdesuso, J.
Hurtado-Martínez and M. Valdés
Percutaneous Coronary Intervention in Octogenarians.
Do they Face a Higher Risk?M. Velazquez, L. Mora, J. Garcia-Tejada, A.
Albarran, F. Hernandez, I. Gomez,
J. Andreu and J. Tascon
The Changing Role of Surgical Coronary
Revascularization: A Contemporary, Decade Experience from a Canadian
Academic InstitutionS.K. Singh, N.P. Fountas, S.E. Fremes and
Effect of Minimal Extracorporal Circulation (MECC)
Compared to Cardiopulmonary Bypass System(CPB) on Organ Function and
Inflammatory Response A Prospective Randomized StudyJ. Schönebeck, U. Mehrmann, M. Haddad, B.
Reiter, B. Dahme, C. Detter and H. Reichenspurner
New Assist Devices for Heart FailureE. Wolner, S. Sandner, D. Zimpfer and G.
Vineberg Procedure – A New Technique J.G. Lobo Filho, A.J.V. Forte, M.C.A.
Leitão and H.G. Lobo Filho
Surgical Myocardial Revascularization and Flow StealA.J.V. Forte, J.G. Lobo Filho, M.C.A.
Leitão, H.G. Lobo Filho and E.R. Carvalho
Left Ventricular Dyssynchrony Is Associated with Poor
Prognosis in Heart Failure Patients Undergoing CABGM. Penicka, J. Bartunek, M. Vanderheyden,
and P. Widimsky On behalf of the Research grant IGA NR: 8524-5 and the
Charles University Prague Research Project MSM 0021620817
Radial Artery Grafts onto the Left Anterior
Descending Coronary Artery: A Safe Alternative to the Left Internal
Mammary ArteryS.K. Singh, N.P. Fountas, D. Petroff, G.N.
Cohen, G.T. Christakis, B.S. Goldman and S.E. Fremes
Initial Impact of DES on Coronary Artery Bypass Graft
in JapanY. Takahara, K. Mogi, M. Hatakeyama and A.
Anomalous Origin of the Circumflex Coronary Artery
from the Right Coronary Artery: Diagnosis and Operative StrategyC.E. Tourmousoglou, S. Lalos, Th. Psarros
and J. Papaioannou
Meta-analyses Comparing Off-Pump Coronary Artery
Bypass Grafting with On-Pump: What Do We ExpectC.E. Tourmousoglou, S. Lalos, Th. Psarros
and J. Papaioannou
Endarterectomy and Combined Stent Removal During
Opcab ProcedureK.D. Triantafillou and S.E. Fragoulis