25th Conference of the European Society for Microcirculation

(August 26-29, 2008, Budapest, Hungary)




The contents of this publication provide sampling review papers from the participants of the 25th Conference of the European Society for Microcirculation held in Budapest, Hungary, August 26-29 2008.

This meeting aimed to accomplish two main goals. First is, to celebrate the 25th Conference, indicating 50 years of history of the European Society for Microcirculation and second is, to involve - as many as possible - scientists working on the field of microcirculation and vascular biology from the Eastern regions of Europe. I believe that both were achieved as indicated by the participation of more than 400 participants, well representing Eastern European countries, but also China, Japan, and Australia.

By now, there is no doubt that understanding the microcirculation of organs and tissues – consisting arterioles, capillaries, venules, lymphatics, blood and lymphatic fluid - is important, not only from physiological point of view to find out how nature solves the difficult problem of supply and collection of substances necessary for tissues to maintain their metabolism, at rest and during increased demand, but it is also crucial to understand the dysfunction of microcirculation in various pathophysiological and diseased conditions, such as hypertension, diabetes, shock, ischemia reperfusion, inflammation, angiogenesis, cancer and metastasis.

To elucidate these aims, special methods, substances and techniques are necessary which are also exciting fields for developments. The great number of high quality, cutting edge scientific presentations and interactions of researchers at the poster boards at the 25th Conference of the European Society for Microcirculation attest that microvascular research, in all its forms - from the architecture of microvascular network through its functional behaviors, to the role of cellular elements of blood and their interaction with microvascular wall - are in the focus of researchers aiming to elucidate mechanisms that can provide understanding of microcirculation and scientific base for treatments of diseases associated with microvascular dysfunction. Thus microcirculation and vascular biology are, and will continue to be exciting and rewarding fields of research for both young investigators and established scientists.

Although, this publication cannot aim to give a cross section of the scientific content of the meeting, it still illustrates the range of exciting topics presented in the fields of Experimental and Clinical microcirculations and that participants represented six continents and most importantly, eight Eastern European countries. Their papers illustrate the research going on in microcirculation from the organ level to the cellular mechanisms or the potential role of progenitor cells. This volume provides a mean for researchers to freely publish their results and ideas, thereby promoting the communication of scientific ideas, which is further facilitated by the fact that this publication will be sent to be indexed in the Current Contents.

I believe that the exciting areas of research sampled here will encourage young researchers to enter a rewarding carrier in science related to microcirculation, lymphatics, blood rheology and vascular biology.

Akos Koller







Microvascular Hemodynamics and Oxygenation During Experimental
Gas Embolism

I.P. Torres Filho, L.N. Torres and B.D. Spiess


The Use of Compartmental Modelling to Evaluate tcpO2 Distribution Rates: Influence of Age

P. Contreiras Pinto, J.G. Morais and L. Monteiro Rodrigues


Particulate Matter Inhalation Impairs Coronary Microvascular Reactivity

A. LeBlanc, Y. Hu, J. Muller-Delp, A. Moseley, B. Chen, D. Frazer, V. Castranova and T. Nurkiewicz


Smoking Induced Pulmonary Vascular Remodeling Primarily Affects Microcirculation

O. Fira-Mladinescu, L. Vasile, C. Fira-Mladinescu, G. Savoiu, A. Raducan, D. Muntean, G. Mihalas and V. Tudorache


Effects of Ethanol Extract from Mrrubium Incisum on Acute Microcirculatory Disturbance in Rats

C. Niu, Z. Zhao, J. Zhang and Y. Ye


Non-Specific Endocytosis and Cholesterol Crystals as a Cause of Endothelial Injury of Mesenterial Vessels in Rats

D.A. Labunskiy, T.A. Fedotova and M.M. Ovchinnikov


Involvement of Ang II in Ischemia-induced Angiogenesis

M. de Gasparo and B.I. Levy


Leukocyte Activation Markers, Nitric Oxide Metabolites and Oxidative Status in Chronic Renal Failure in Conservative Therapy

G. Caimi, C. Carollo, M. Montana, F. Vaccaro, A. Romano and R. Lo Presti


A Role for Peripheral Tachykinins and the Neurokinin 1 Receptor in the Regulation of Platelet Thrombus Formation

S. Jones, W.J. Kaiser, K.L. Tucker, T. Sage, N.E. Barrett, P.J. Lowry, A. Zimmer, S.P. Hunt, M. Emerson and J.M. Gibbins


Platelet and Leukocyte Adhesion in the Microvasculature at the Cerebral Surface Immediately After Subarachnoid Hemorrhage

M. Ishikawa, G. Kusaka, N. Yamaguchi, E. Sekizuka, H. Nakadate, H. Minamitani, S. Shinoda and E. Watanabe




Dilations of Middle Cerebral Arteries of Salt Sensitive-Rats Are Restored by Receiving Portions of Brown Norway Chromosome 13 Containing the BN Renin Allele

I. Drenjancevic-Peric, M. Durand, C. Moreno-Quinn and J.H. Lombard


Essential Hypertension: Elastase, Nitric Oxide Metabolites and Oxidative Status

R. Lo Presti, C. Carollo, G. Mulè, M. Montana, A. Catania and G. Caimi


Endothelial Dysfunction in Hypertension

P. Poredos


Vascular Endothelial Growth Factor (VEGF) Isoforms May Regulate Sex-Specific Vascular Development, Cord Formation and Follicle Progression In Developing Gonads

A.S. Cupp, R.C. Bott, R.M. Pohlmann, R.A. Ten Broeck and D.T. Clopton


Ambivalence of Progenitor Cells in Vascular Repair

C. Weber




Omental Microcirculation During Free Omental Flap Autotransplantation in Dogs: Intraoperative Monitoring by Laser Doppler Tissue Flowmetry

J. Pap-Szekeres, M. Svebis, Zs. Domjan, G. Cserni, N. Nemeth, I. Furka and I. Miko


Imaging and Manipulation of Cells and Molecules with Atomic Force Microscopy and Fluorescence-AFM Combinations: Application to Cellular Mechanics

T. Huber, D. Szatmari, Z. Martonfalvi, U. Murvai, B. Kiss, A. Karsai, L. Grama and M.S.Z. Kellermayer


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